Szikszay M, Benedek G
Department of Physiology, University Medical School of Szeged, Hungary.
Acta Physiol Hung. 1989;73(4):447-53.
Pain-sensitivity as well as the analgesic and thermoregulatory effects of morphine were studied after two different types of chronic environmental stresses in rats (extra stimulation of newborns for 21 days, or social isolation for a month in adult age). The basal pain sensitivity and the base-line body temperature were similarly affected after the two interventions: an increased tail-flick latency, a decreased hot-plate latency and a decreased body temperature were noted. The analgesic and thermoregulatory effects of morphine were uniformly reduced in rats exposed to either stress. These findings suggest a common effect of various non painful mild environmental stresses on the activity of the endogenous opioid system.
在对大鼠施加两种不同类型的慢性环境应激（对新生大鼠进行21天的额外刺激，或在成年期将其隔离一个月）后，研究了疼痛敏感性以及吗啡的镇痛和体温调节作用。两种干预后，基础疼痛敏感性和基线体温受到类似影响：甩尾潜伏期延长、热板潜伏期缩短以及体温降低。在受到任何一种应激的大鼠中，吗啡的镇痛和体温调节作用均一致降低。这些发现表明，各种非疼痛性轻度环境应激对内源性阿片系统的活性具有共同影响。
