Ritzenthaler Thomas, Luis David, Hullin Thomas, Fayssoil Abdallah
AP-HP, CHU Raymond-Poincaré, réanimation médico-chirurgicale et pôle ventilation à domicile, 92380 Garches, France.
AP-HP, CHU Raymond-Poincaré, réanimation médico-chirurgicale et pôle ventilation à domicile, 92380 Garches, France.
Presse Med. 2015 May;44(5):492-7. doi: 10.1016/j.lpm.2015.01.008. Epub 2015 Apr 15.
Mitochondrial diseases are multi-system disorders in relation with mitochondrial DNA and/or nuclear DNA abnormalities. Clinical pictures are heterogeneous, involving endocrine, cardiac, neurologic or sensory systems. Cardiac involvements are morphological and electrical disturbances. Prognosis is worsened in case of cardiac impairment. Treatments are related to the type of cardiac dysfunction including medication or pacemaker implantation.
线粒体疾病是与线粒体DNA和/或核DNA异常相关的多系统疾病。临床表现具有异质性，累及内分泌、心脏、神经或感觉系统。心脏受累表现为形态学和电活动紊乱。若出现心脏损害，预后会恶化。治疗方法与心脏功能障碍的类型有关，包括药物治疗或起搏器植入。
