Rubio-Abadal E, Ochoa S, Barajas A, Baños I, Dolz M, Sanchez B, Del Cacho N, Carlson J, Huerta-Ramos E, Usall J
Research Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona (UB), CIBERSAM, GTRDSM, C/ Antoni Pujadas, 42, 08830, Sant Boi de Llobregat, Barcelona, Spain.
Research Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona (UB), CIBERSAM, GTRDSM, C/ Antoni Pujadas, 42, 08830, Sant Boi de Llobregat, Barcelona, Spain.
J Psychiatr Res. 2015 Jun;65:108-14. doi: 10.1016/j.jpsychires.2015.03.018. Epub 2015 Mar 27.
Earlier age at onset of psychosis (AOP) has been associated with poor social adjustment and clinical outcome. Genetic and environmental factors such as obstetric complications, parental history of psychosis, advanced paternal age at time of birth, low birth weight and gestational age, and use of drugs have been described as bringing AOP forward. This study aims to evaluate the relationship between AOP and these factors in a sample of first episode of psychosis (FEP) patients.
Clinical and sociodemographic data, age at FEP, age of parents at birth, parental history of psychosis, drug-use habits of the mother during pregnancy and of the patient before psychotic onset, and Lewis and Murray obstetric complication scale were obtained from 90 patients with FEP. Statistical analysis was performed by means of Pearson correlations, Chi-square tests, Student T-test analyses and a linear regression model using SPSS version 22.
Pre-eclampsia, need for incubator at birth, use of forceps, parental history of psychosis, and low birth weight were associated with an earlier AOP. Use of forceps and birth weight are the variables which best predict AOP in FEP. Stimulant drugs, which were mostly used together with cannabis and cocaine, were the only substances associated with an earlier AOP.
Our findings are consistent with previous study results and underline the role of the prenatal period in the development of psychosis and the importance of careful monitoring of pregnancy and delivery, especially in cases with familial history.
精神病发病年龄（AOP）较早与社会适应不良和临床结局较差有关。遗传和环境因素，如产科并发症、父母精神病病史、父亲生育时年龄较大、低出生体重和孕周，以及药物使用，都被认为会导致AOP提前。本研究旨在评估首次发作精神病（FEP）患者样本中AOP与这些因素之间的关系。
从90例FEP患者中获取临床和社会人口学数据、FEP发病年龄、父母生育时年龄、父母精神病病史、母亲孕期及患者精神病发作前的药物使用习惯，以及Lewis和Murray产科并发症量表。使用SPSS 22版通过Pearson相关性分析、卡方检验、学生t检验分析和线性回归模型进行统计分析。
子痫前期、出生时需要使用孵化器、使用产钳、父母精神病病史和低出生体重与较早的AOP相关。使用产钳和出生体重是FEP中最能预测AOP的变量。主要与大麻和可卡因一起使用的兴奋剂药物是唯一与较早AOP相关的物质。
我们的研究结果与先前的研究结果一致，并强调了孕期在精神病发展中的作用，以及仔细监测妊娠和分娩的重要性，尤其是在有家族病史的情况下。
