Stefańska Joanna, Antoszczak Michał, Stępień Karolina, Bartoszcze Michał, Mirski Tomasz, Huczyński Adam
Medical University of Warsaw, Department of Pharmaceutical Microbiology, Oczki 3, 02-007 Warsaw, Poland.
Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89 b, 61-614 Poznań, Poland.
Bioorg Med Chem Lett. 2015;25(10):2082-8. doi: 10.1016/j.bmcl.2015.03.085. Epub 2015 Apr 4.
For the first time, a series of tertiary amides of polyether antibiotic-Salinomycin have been obtained and screened for their antibacterial activity against different strains of bacteria, including Bacillus anthracis and clinical methicillin-resistant Staphylococcus epidermidis (MRSE). Moreover, biofilm inhibition of MRSE and genotoxicity tests against Bacillus subtilis have been performed. Our studies show that Salinomycin and its some derivatives are active against tested bacteria and exhibited definitely bacteriostatic, not bactericidal activity.
首次获得了一系列聚醚抗生素盐霉素的叔酰胺，并对其针对不同细菌菌株（包括炭疽芽孢杆菌和临床耐甲氧西林表皮葡萄球菌（MRSE））的抗菌活性进行了筛选。此外，还进行了MRSE的生物膜抑制试验以及针对枯草芽孢杆菌的遗传毒性试验。我们的研究表明，盐霉素及其一些衍生物对受试细菌具有活性，并且表现出明确的抑菌而非杀菌活性。
