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地中海斑疹热和听力障碍:一种罕见的并发症。

Mediterranean spotted fever and hearing impairment: a rare complication.

机构信息

U.O. Ematologia non tumorale e coagulopatie Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Milan, Italy.

Università degli Studi di Milano.

出版信息

Int J Infect Dis. 2015 Jun;35:34-6. doi: 10.1016/j.ijid.2015.04.005. Epub 2015 Apr 16.

Abstract

Mediterranean spotted fever (MSF) is caused by Rickettsia conorii and transmitted by the brown dog tick Rhipicephalus sanguineus. It is prevalent in southern Europe, Africa and central Asia. The disease usually has a benign course and is characterized by fever, myalgia and a characteristic papular rash with an inoculation eschar ('tache noir') at the site of the tick bite. Severe forms of disease can have cardiac, neurologic or renal involvement. Nervous system complications are unusual and may develop in the early phase of disease or as a delayed complication. Neurological symptoms include headache and alterations of the level of consciousness, and some cases of meningoenchefalitis and Guillain-Barrè syndrome have been also reported. Peripheral nerve involvement is reported only in a limited number of case reports. We describe a case of Rickettsia conorii that was complicated with hearing loss and did not respond to specific treatment. Hearing loss is a rare event, but clinicians should be aware of this complication.

摘要

地中海斑疹热(MSF)由康氏立克次体引起,由棕色犬蜱(Rhipicephalus sanguineus)传播。它在南欧、非洲和中亚流行。该病通常病程良性,以发热、肌痛和特征性斑丘疹为特征,蜱叮咬部位有接种性焦痂(“黑斑”)。严重的疾病可能累及心脏、神经或肾脏。神经系统并发症不常见,可能在疾病早期或作为迟发性并发症发生。神经系统症状包括头痛和意识水平改变,也有报道称出现脑膜脑炎和格林-巴利综合征。周围神经受累仅在少数病例报告中报道。我们描述了一例感染康氏立克次体的病例,该病例并发听力损失且对特定治疗无反应。听力损失是一种罕见的事件,但临床医生应意识到这种并发症。

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