Institut de Chimie des Substances Naturelles, CNRS, Univ. Paris-Sud, 91198 Gif-sur-Yvette Cedex (France), Fax: (+33) 1-69077247.
Chemistry. 2015 Jun 1;21(23):8399-402. doi: 10.1002/chem.201500749. Epub 2015 Apr 17.
A highly enantio- and diastereoselective synthesis of 3-aminocyclopenta[b]indoles has been developed through formal [3+2] cycloaddition reaction of enecarbamates and 3-indolylmethanols. This transformation is catalyzed by a chiral phosphoric acid that achieves simultaneous activation of both partners of the cycloaddition. Mechanistic data are also presented that suggest that the reaction occurs through a stepwise pathway.
通过烯基氨基甲酸酯和 3-吲哚甲醇的[3+2]环加成反应，开发了一种高对映选择性和非对映选择性的 3-氨基环戊[b]吲哚的合成方法。这种转化是由手性磷酸催化的，它可以同时激活环加成的两个反应物。还提出了反应通过逐步途径进行的机理数据。
