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妊娠合并原发性甲状旁腺功能亢进症:两例报告并文献复习

Primary hyperparathyroidism in pregnancy: a two-case report and literature review.

作者信息

Herrera-Martínez A D, Bahamondes-Opazo R, Palomares-Ortega R, Muñoz-Jiménez C, Gálvez-Moreno M A, Quesada Gómez J M

机构信息

Department of Endocrinology and Nutrition, Reina Sofia University Hospital, Avenida Menéndez Pidal, s/n, 14004 Córdoba, Spain.

出版信息

Case Rep Obstet Gynecol. 2015;2015:171828. doi: 10.1155/2015/171828. Epub 2015 Mar 29.

Abstract

Primary hyperparathyroidism (PHPT) in pregnant women is an uncommon disease. It could be easily misdiagnosed because of physiologic changes during pregnancy; in some cases, patients could remain asymptomatic maintaining elevated calcium serum levels, and this situation represents a threat to the health of both mother and fetus. We present two cases of PHPT during pregnancy and their evolution after surgical treatment in the second trimester; there were no observed complications during pregnancy or delivery in our patients. Early diagnosis and medical/surgical treatment in PHPT are necessary for avoiding maternal and fetal complications which could not be predicted based on duration or severity of hypercalcemia. An appropriate management of PHPT during pregnancy is necessary for preserving the health of both the woman and the fetus.

摘要

孕妇原发性甲状旁腺功能亢进症(PHPT)是一种罕见疾病。由于孕期的生理变化,该病很容易被误诊;在某些情况下,患者可能无症状,但血清钙水平持续升高,这种情况对母亲和胎儿的健康都构成威胁。我们介绍两例孕期PHPT病例及其在孕中期手术治疗后的病情发展;我们的患者在孕期或分娩期间均未观察到并发症。对于PHPT,早期诊断和药物/手术治疗对于避免母婴并发症是必要的,而这些并发症无法根据高钙血症的持续时间或严重程度来预测。孕期对PHPT进行适当管理对于保护女性和胎儿的健康都是必要的。

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本文引用的文献

1
Primary hyperparathyroidism: an overview.原发性甲状旁腺功能亢进症:概述。
Int J Endocrinol. 2011;2011:251410. doi: 10.1155/2011/251410. Epub 2011 Jun 2.
2
Primary hyperparathyroidism and pregnancy.原发性甲状旁腺功能亢进症与妊娠
Proc (Bayl Univ Med Cent). 2011 Jul;24(3):220-3. doi: 10.1080/08998280.2011.11928719.
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Primary hyperparathyroidism.原发性甲状旁腺功能亢进症
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Hyperparathyroidism.甲状旁腺功能亢进症。
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