Pedersen Ellen Bøtker, Ebbehøj N E, Göen T, Meyer H W, Jacobsen P
Department of Occupational and Environmental Medicine, Copenhagen University, Bispebjerg Hospital, 2400, Copenhagen NV, Denmark.
Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Int Arch Occup Environ Health. 2016 Jan;89(1):43-7. doi: 10.1007/s00420-015-1050-1. Epub 2015 Apr 17.
To assess the exposure to a broad-spectrum of polychlorinated biphenyl congeners (PCBs) from the indoor environment through bio-monitoring of people working in a building with PCB-containing materials and elevated PCB levels in the indoor air.
A cross-sectional study comparing the plasma concentration of 27 PCB congeners in 15 people working in a PCB-contaminated building and 30 matched controls.
Median concentration of eight low-chlorinated PCB congeners was significantly higher in the exposed than in the control group. The sum of median concentrations of tri + tetra-chlorinated PCB was almost ten times higher in the exposed group than in the unexposed, and sums of dioxin-like and non-dioxin-like PCB were both relatively increased by 60 % in the exposed group.
The occupational indoor environment may significantly add to PCB exposure, especially to the lower-chlorinated congeners. Health effect from this little-acknowledged exposure has not yet been documented, but data supporting lack of effect are sparse and research generating information on effect of exposure to specific congeners including at levels relevant for the indoor environment should be encouraged.
通过对在含有多氯联苯材料且室内空气中多氯联苯水平升高的建筑物中工作的人员进行生物监测，评估其从室内环境中接触多种多氯联苯同系物（PCBs）的情况。
一项横断面研究，比较了15名在受多氯联苯污染的建筑物中工作的人员与30名匹配对照者血浆中27种多氯联苯同系物的浓度。
暴露组中8种低氯多氯联苯同系物的中位浓度显著高于对照组。暴露组中三氯 + 四氯多氯联苯中位浓度之和几乎是未暴露组的10倍，且暴露组中二噁英类和非二噁英类多氯联苯的总和均相对增加了60%。
职业性室内环境可能会显著增加多氯联苯的暴露，尤其是低氯同系物。这种鲜为人知的暴露对健康的影响尚未有文献记载，但支持无影响的数据稀少，应鼓励开展研究以获取有关接触特定同系物（包括与室内环境相关水平）影响的信息。
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