Yan Jiaqing, Wei Yun, Wang Yinghua, Xu Gang, Li Zheng, Li Xiaoli
Yanshan University, Institute of Electrical Engineering, No. 438, Hebei Street, Haigang District, Qinhuangdao 066004, China.
Beijing Normal University, State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, No. 19, XinJieKouWai Street, HaiDian District, Beijing 100875, ChinacBeijing Normal University, Center for Collaboration an.
J Biomed Opt. 2015 Apr;20(4):46007. doi: 10.1117/1.JBO.20.4.046007.
Transcranial direct current stimulation (tDCS) is a noninvasive, safe and convenient neuro-modulatory technique in neurological rehabilitation, treatment, and other aspects of brain disorders. However, evaluating the effects of tDCS is still difficult. We aimed to evaluate the effects of tDCS using hemodynamic changes using functional near-infrared spectroscopy (fNIRS). Five healthy participants were employed and anodal tDCS was applied to the left motor-related cortex, with cathodes positioned on the right dorsolateral supraorbital area. fNIRS data were collected from the right motor-related area at the same time. Functional connectivity (FC)between intracortical regions was calculated between fNIRS channels using a minimum variance distortion-less response magnitude squared coherence (MVDR-MSC) method. The levels of Oxy-HbO change and the FC between channels during the prestimulation, stimulation, and poststimulation stages were compared. Results showed no significant level difference, but the FC measured by MVDR-MSC significantly decreased during tDCS compared with pre-tDCS and post-tDCS, although the FC difference between pre-tDCS and post-tDCS was not significant. We conclude that coherence calculated from resting state fNIRS may be a useful tool for evaluating the effects of anodal tDCS and optimizing parameters for tDCS application.
经颅直流电刺激（tDCS）是一种用于神经康复、治疗及脑部疾病其他方面的无创、安全且便捷的神经调节技术。然而，评估tDCS的效果仍然困难。我们旨在使用功能近红外光谱（fNIRS）通过血流动力学变化来评估tDCS的效果。招募了5名健康参与者，将阳极tDCS应用于左侧运动相关皮层，阴极置于右侧眶上外侧区。同时从右侧运动相关区域收集fNIRS数据。使用最小方差无失真响应幅度平方相干（MVDR-MSC）方法计算fNIRS通道之间皮质内区域的功能连接（FC）。比较了刺激前、刺激期间和刺激后阶段氧合血红蛋白（Oxy-HbO）变化水平及通道间的FC。结果显示水平差异无统计学意义，但与刺激前和刺激后相比，MVDR-MSC测量的FC在tDCS期间显著降低，尽管刺激前和刺激后的FC差异不显著。我们得出结论，从静息态fNIRS计算得出的相干性可能是评估阳极tDCS效果及优化tDCS应用参数的有用工具。
