Lee Gihyoun, Lee Jungsoo, Kim Jinuk, Kim Heegoo, Chang Won Hyuk, Kim Yun-Hee
Department of Health Sciences and Technology, The Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul 06351, Korea.
Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
J Pers Med. 2022 Mar 10;12(3):432. doi: 10.3390/jpm12030432.
In this study, the effective application of high-definition transcranial direct current stimulation (HD-tDCS) based on the whole brain hemodynamic response in stroke patients was investigated using functional near-infrared spectroscopy (fNIRS). The intrahemispheric and interhemispheric synchronization and cortical activity based on the time during 1 mA HD-tDCS were examined in 26 chronic cerebrovascular disease patients. At the beginning of HD-tDCS, the synchronization and brain activity in the whole brain increased rapidly and decreased after 5 min. In the middle of tDCS, the synchronization began to increase again, and strong synchronic connections were formed around the desired stimulation area. After tDCS, strong cortical activation was observed in the stimulation area, indicating that the baseline of the oxyhemoglobin (HbO) signal increased in the desired stimulation area. Therefore, the results of this study indicate that HD-tDCS can be applied efficiently to enhance the effect of tDCS. This stimulation method with tDCS can be explored clinically for more neurorehabilitation of patients with degenerative brain diseases.
在本研究中，使用功能近红外光谱（fNIRS）研究了基于全脑血流动力学反应的高清经颅直流电刺激（HD-tDCS）在中风患者中的有效应用。在26例慢性脑血管疾病患者中，检测了基于1 mA HD-tDCS期间的半球内和半球间同步性以及皮质活动。在HD-tDCS开始时，全脑的同步性和脑活动迅速增加，并在5分钟后下降。在tDCS进行过程中，同步性再次开始增加，并在期望的刺激区域周围形成了强烈的同步连接。tDCS后，在刺激区域观察到强烈的皮质激活，表明在期望的刺激区域氧合血红蛋白（HbO）信号的基线增加。因此，本研究结果表明HD-tDCS可以有效地应用于增强tDCS的效果。这种结合tDCS的刺激方法可在临床上探索用于更多退行性脑疾病患者的神经康复。
