吲哚美辛对妊娠期降压药物治疗的拮抗作用？

Antagonism of antihypertensive drug therapy in pregnancy by indomethacin?

作者信息

Schoenfeld A, Freedman S, Hod M, Ovadia Y

机构信息

Department of Obstetric and Gynecology, Beilins on Medical Center, Tel Aviv University Medical School, Petah Tikva, Israel.

出版信息

Am J Obstet Gynecol. 1989 Nov;161(5):1204-5. doi: 10.1016/0002-9378(89)90666-2.

DOI:10.1016/0002-9378(89)90666-2

PMID:2589441

Abstract

Two women with preeclampsia treated with pindolol and propranolol became profoundly hypertensive when indomethacin was added because of premature contractions. The interaction of nonsteroidal antiinflammatory agents and beta-blockers and their role in the control of blood pressure in obstetrics are discussed. Indomethacin should not be given to pregnant patients with hypertension treated with beta-blockers.

摘要

两名患有先兆子痫的女性在使用吲哚洛尔和普萘洛尔治疗时，因出现早产宫缩而加用吲哚美辛后，血压急剧升高。本文讨论了非甾体类抗炎药与β受体阻滞剂的相互作用及其在产科血压控制中的作用。不应给正在接受β受体阻滞剂治疗的高血压孕妇使用吲哚美辛。