Andrews Sophie C, Domínguez Juan F, Mercieca Emily-Clare, Georgiou-Karistianis Nellie, Stout Julie C
School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia.
Neurodegener Dis Manag. 2015;5(2):155-64. doi: 10.2217/nmt.14.58.
In Huntington's disease (HD), there is growing evidence of neural compensation during neurodegeneration, and that these processes might be modifiable by environmental factors. Cognitive intervention to improve brain function has been trialled only to a very limited extent in HD; however, it has shown promise in other neurodegenerative diseases. In this review, we discuss the evidence for the use of cognitive intervention to boost neural compensation in HD, and find it has potential to delay clinical decline, particularly if applied early in the disease process. Randomized controlled trials of cognitive intervention in HD should be implemented as a next step to gauging the efficacy of this approach to improve outcomes for those with the HD gene.
在亨廷顿舞蹈症（HD）中，越来越多的证据表明在神经退行性变过程中存在神经代偿，并且这些过程可能会受到环境因素的影响。改善脑功能的认知干预在HD中仅进行了非常有限的试验；然而，它在其他神经退行性疾病中已显示出前景。在本综述中，我们讨论了使用认知干预来促进HD神经代偿的证据，并发现它有可能延缓临床衰退，特别是如果在疾病过程早期应用。作为衡量这种方法对HD基因携带者改善预后效果的下一步，应开展HD认知干预的随机对照试验。
