Zhang Yong, Li Ao, Peng Weizhen, Sun Jue, Xu Fangming, Xu Jianhua
Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 164 Lanxi Road, Putuo District, Shanghai, 200062, China.
Tumour Biol. 2015 Sep;36(10):7399-407. doi: 10.1007/s13277-015-3434-y. Epub 2015 Apr 21.
Removal of primary tumors often leads to increases in growth of metastatic tumor cells. Thus, development of an efficient treatment to inhibit the growth of metastatic tumor cells after resection of primary tumors appears to be critical for cancer therapy. Here, we reported that administration of a Chinese medicine Shiquandabutao (SQDBT) after removal of the primary cancer significantly inhibited the growth of metastatic cancer cells in mouse liver. Further analyses showed that the effect of SQDBT resulted from one of its main component, Siwutang (SWT), rather than from another main component, Sijunzitang (SJZT). Moreover, we found that the soluble Flt-1 from SWT neutralized the increased placental growth factor (PLGF) secreted by the metastatic cancer cells after primary cancer resection and subsequently inhibited the cancer neovascularization to suppress the metastatic cancer growth. Thus, our study reveals an essential role of SQDBT in inhibiting the growth of metastatic cancer after removal of primary cancer and further highlights PLGF as a potential target for metastatic cancer treatment.
原发性肿瘤的切除往往会导致转移性肿瘤细胞生长增加。因此，开发一种有效的治疗方法来抑制原发性肿瘤切除后转移性肿瘤细胞的生长，对于癌症治疗似乎至关重要。在此，我们报告称，在切除原发性癌症后给予中药十全大补汤（SQDBT）可显著抑制小鼠肝脏中转移性癌细胞的生长。进一步分析表明，SQDBT的作用源于其主要成分之一四物汤（SWT），而非另一种主要成分四君子汤（SJZT）。此外，我们发现SWT中的可溶性Flt-1中和了原发性癌症切除后转移性癌细胞分泌的增加的胎盘生长因子（PLGF），随后抑制了癌症新血管生成，从而抑制转移性癌症生长。因此，我们的研究揭示了SQDBT在抑制原发性癌症切除后转移性癌症生长中的重要作用，并进一步强调PLGF作为转移性癌症治疗的潜在靶点。
