对患有亚临床甲状腺功能减退症的阿尔茨海默病患者的局部脑血流量评估。
Evaluation of regional cerebral blood flow in Alzheimer's disease patients with subclinical hypothyroidism.
作者信息
Haji Megumi, Kimura Noriyuki, Hanaoka Takuya, Aso Yasuhiro, Takemaru Makoto, Hirano Teruyuki, Matsubara Etsuro
机构信息
Department of Neurology, Faculty of Medicine, Oita University, Oita, Japan.
出版信息
Dement Geriatr Cogn Disord. 2015;39(5-6):360-7. doi: 10.1159/000375298. Epub 2015 Apr 14.
BACKGROUND
This study examined regional cerebral blood flow (rCBF) in Alzheimer's disease (AD) patients with and without subclinical hypothyroidism (SCH).
METHODS
Eleven AD patients with SCH and 141 AD patients without SCH underwent brain perfusion single photon emission computed tomography (SPECT). The SPECT data were analyzed by statistical parametric mapping (SPM8) and FineSRT.
RESULTS
AD patients with SCH showed a significantly decreased rCBF mainly in the temporal lobe and thalamus, whereas those without SCH showed a significantly decreased rCBF in the parietotemporal lobe and cingulate gyrus as well as the frontal lobe.
CONCLUSION
Our findings suggest that SCH may affect cerebral perfusion in regions associated with the memory function.
背景
本研究调查了患有和未患有亚临床甲状腺功能减退症（SCH）的阿尔茨海默病（AD）患者的局部脑血流量（rCBF）。
方法
11名患有SCH的AD患者和141名未患有SCH的AD患者接受了脑灌注单光子发射计算机断层扫描（SPECT）。通过统计参数映射（SPM8）和FineSRT对SPECT数据进行分析。
结果
患有SCH的AD患者主要在颞叶和丘脑显示rCBF显著降低，而未患有SCH的患者在顶颞叶、扣带回以及额叶显示rCBF显著降低。
结论
我们的研究结果表明，SCH可能会影响与记忆功能相关区域的脑灌注。
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