Kolaj-Robin Olga, Russell David, Hayes Kevin A, Pembroke J Tony, Soulimane Tewfik
Department of Chemical & Environmental Sciences, and Materials and Surface Science Institute, University of Limerick, Limerick, Ireland.
Department of Chemical & Environmental Sciences, and Materials and Surface Science Institute, University of Limerick, Limerick, Ireland.
FEBS Lett. 2015 May 22;589(12):1283-95. doi: 10.1016/j.febslet.2015.04.007. Epub 2015 Apr 17.
The Cation Diffusion Facilitators (CDFs) form a family of membrane-bound proteins capable of transporting zinc and other heavy metal ions. Involved in metal tolerance/resistance by efflux of ions, CDF proteins share a two-modular architecture consisting of a transmembrane domain (TMD) and C-terminal domain (CTD) that protrudes into the cytoplasm. Discovery of a Zn²⁺ and Cd²⁺ CDF transporter from a marine bacterium Maricaulis maris that does not possess the CTD questions current perceptions regarding this family of proteins. This article describes a new, CTD-lacking subfamily of CDFs and our current knowledge about this family of proteins in the view of these findings.
阳离子扩散促进因子（CDFs）构成了一类膜结合蛋白家族，能够转运锌和其他重金属离子。CDF蛋白通过离子外流参与金属耐受性/抗性，它们具有由跨膜结构域（TMD）和伸入细胞质的C端结构域（CTD）组成的双模块结构。从海洋细菌马里考利斯海杆菌中发现的一种缺乏CTD的Zn²⁺和Cd²⁺ CDF转运蛋白，对目前关于该蛋白家族的认识提出了质疑。本文鉴于这些发现描述了一个新的、缺乏CTD的CDF亚家族以及我们目前对该蛋白家族的了解。
