单卵双胞胎的下颌形态：一项头影测量研究。

Mandibular morphology in monozygotic twins: a cephalometric study.

作者信息

Šidlauskas Mantas, Šalomskienė Loreta, Andriuškevičiūtė Irena, Šidlauskienė Monika, Labanauskas Žygimantas, Šidlauskas Antanas

机构信息

Medical Academy, Lithuanian University of Health Sciences, J.Lukšos-Daumanto str. 6, LT-50106 Kaunas, Lithuania.

出版信息

Stomatologija. 2014;16(4):137-43.

PMID:25896038

Abstract

BACKGROUND

The understanding of relative effects of genetics and environmental factors on mandible growth would increase effectiveness of orthodontic therapy and treatment planning. The purpose of this study was to clarify whether the skeletal morphology of mandible is phenotypically alike in two individuals in a pair of young adult monozygotic (MZ) twins.

METHODS

The 90 twin pairs were classified as MZ by 15 specific DNA markers and Amel fragment. Cephalometric analysis of mandible morphology using 27 parameters was done and Pearson's intra-pair correlation coefficient for each variable was calculated.

RESULTS

The highest correlations of cephalometric variables between two individuals in the same MZ twins pair was in the total mandibular and corpus length (r=0.94). The lowest correlations was established for depth of antigonial notch (r=0.65) and articular angle (r=0.68) in female pairs. Statistically significant differences (p ≤ 0.05) of intra-pair correlation coefficients between genders was found only for total mandibular length (distances Co-Gn and Ar-Gn).

CONCLUSIONS

Mandibular length has highest intra-pair correlation coefficient among similar linear cephalometric variables in MZ twins. The females demonstrated greater variability of mandible skeletal cephalometric measurements within the MZ twin pair than the men.

摘要

背景

了解遗传和环境因素对下颌骨生长的相对影响，将提高正畸治疗和治疗计划的有效性。本研究的目的是阐明一对年轻成年同卵（MZ）双胞胎中两人的下颌骨骨骼形态在表型上是否相似。

方法

通过15个特定的DNA标记和牙釉质片段将90对双胞胎分类为MZ。使用27个参数对下颌骨形态进行头影测量分析，并计算每个变量的Pearson组内相关系数。

结果

同一MZ双胞胎对中两人之间头影测量变量的最高相关性出现在下颌骨总长和体部长度上（r = 0.94）。女性双胞胎对中，下颌角切迹深度（r = 0.65）和关节角（r = 0.68）的相关性最低。仅在下颌骨总长（Co-Gn和Ar-Gn距离）方面发现性别之间的组内相关系数存在统计学显著差异（p≤0.05）。