Xue Zhan-Cheng, Wang Chuang, Wang Qin-Wen, Zhang Jun-Fang
School of Medicine, Ningbo University, Ningbo 315211, China.
Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China.
Sheng Li Xue Bao. 2015 Apr 25;67(2):155-62.
The cAMP-responsive element binding protein (CREB)-regulated transcription coactivator, CRTC (also known as transducer of regulated CREB, TORC), is identified as a potent modulator of cAMP response element (CRE)-driven gene transcription. The CRTC family consists of three members (CRTC1-3), among which the CRTC1 shows the highest expression in the brain. Several studies have demonstrated that the CRTC1 plays critical roles in neuronal dendritic growth, long-term synaptic plasticity, memory consolidation and reconsolidation etc., whereas dysfunction of CRTC1 is mainly involved in neurodegenerative disorders. In light of these findings, we aim to review recent research reports that indicate the CRTC1 dysfunction and its underlying mechanisms in the neurodegenerative disorders.
环磷酸腺苷反应元件结合蛋白（CREB）调节的转录共激活因子CRTC（也称为调节性CREB转导子，TORC）被确定为环磷酸腺苷反应元件（CRE）驱动的基因转录的有效调节因子。CRTC家族由三个成员（CRTC1 - 3）组成，其中CRTC1在大脑中的表达最高。多项研究表明，CRTC1在神经元树突生长、长期突触可塑性、记忆巩固和再巩固等方面发挥着关键作用，而CRTC1功能障碍主要与神经退行性疾病有关。鉴于这些发现，我们旨在综述近期表明CRTC1功能障碍及其在神经退行性疾病中的潜在机制的研究报告。
