加拿大医院耐万古霉素肠球菌的流行病学（CANWARD研究，2007年至2013年）
Epidemiology of vancomycin-resistant enterococci in Canadian hospitals (CANWARD study, 2007 to 2013).
作者信息
Simner P J, Adam H, Baxter M, McCracken M, Golding G, Karlowsky J A, Nichol K, Lagacé-Wiens P, Gilmour M W, Hoban D J, Zhanel G G
机构信息
Diagnostic Services Manitoba, Winnipeg, Manitoba, Canada University of Manitoba, Department of Medical Microbiology and Infectious Diseases, Winnipeg, Manitoba, Canada
Diagnostic Services Manitoba, Winnipeg, Manitoba, Canada University of Manitoba, Department of Medical Microbiology and Infectious Diseases, Winnipeg, Manitoba, Canada.
出版信息
Antimicrob Agents Chemother. 2015 Jul;59(7):4315-7. doi: 10.1128/AAC.00384-15. Epub 2015 Apr 20.
Abstract
Of 1,927 Enterococcus species isolates collected across Canada from 2007 to 2013, 80 (4.2%) were identified as vancomycin-resistant enterococci (VRE). VRE infections during this time tripled in Canadian hospitals, from 1.8% to 6.0% (P = 0.03). All VRE were Enterococcus faecium, with 90% possessing vanA. The prevalence of vanB decreased from 37.5% in 2007 to 0% in 2013 (P < 0.05). The VRE were multidrug resistant, but 70.6%, 86.3%, and 100% were susceptible to doxycycline, linezolid, and daptomycin, respectively.
摘要
在2007年至2013年期间从加拿大各地收集的1927株肠球菌分离株中，有80株（4.2%）被鉴定为耐万古霉素肠球菌（VRE）。在此期间，加拿大医院的VRE感染率增长了两倍，从1.8%升至6.0%（P = 0.03）。所有VRE均为粪肠球菌，其中90%携带vanA。vanB的流行率从2007年的37.5%降至2013年的0%（P < 0.05）。VRE具有多重耐药性，但分别有70.6%、86.3%和100%对强力霉素、利奈唑胺和达托霉素敏感。
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