Suresh Ernest, Abrahamsen Bo
Senior Consultant Rheumatologist, Department of Medicine, Alexandra Hospital (Jurong Health), Singapore. E-mail:
Professor of Endocrinology, Odense Patient Data Exploratory Network (OPEN), Institute of Clinical Research, University of Southern Denmark, Odense.
Cleve Clin J Med. 2015 Feb;82(2):105-14. doi: 10.3949/ccjm.82a.13173.
Denosumab is a novel antiresorptive drug that has been approved for use as a first-line drug for primary and secondary prevention of osteoporotic fractures. The authors discuss the mechanism of action of denosumab, review the evidence for its efficacy and safety in patients with osteoporosis, and offer recommendations for its use in clinical practice.
地诺单抗是一种新型抗骨吸收药物,已被批准用作预防骨质疏松性骨折的一线药物,用于一级和二级预防。作者讨论了地诺单抗的作用机制,回顾了其在骨质疏松症患者中疗效和安全性的证据,并为其在临床实践中的应用提供了建议。