Moraes Cristiane, Marinho Sandra, Lobo Julie Calixto, Stockler-Pinto Milena B, Barros Amanda F, Jacobson Ludmilla Viana, da Nobrega Antonio Claudio Lucas, Rosa Maria Luiza Garcia, Denise Mafra
a Graduate Program in Cardiovascular Sciences, Hospital Universitário Antônio Pedro, Unidade de Pesquisa Clínica, Fluminense Federal University (UFF) , Niterói, Rio de Janeiro , Brazil .
Ren Fail. 2015 Jun;37(5):851-7. doi: 10.3109/0886022X.2015.1033634. Epub 2015 Apr 21.
Patients undergoing hemodialysis (HD) present altered levels of appetite hormones such as acyl-ghrelin (orexigenic) and obestatin (anorexigenic), which may contribute to anorexia. Physical exercise may affect these hormones and improve appetite in these patients.
The objective of this study is to evaluate the effects of a resistance exercise program in appetite hormones, body composition, and nutritional status in HD patients.
Intervention study with the control group.
Fifty-two patients on regular HD program were enrolled into two groups: 37 patients performed exercises (56.7% male, 45 ± 12.8 years, 57 (9-192) months on HD) and 15 patients comprised the control group (66.7% men, 50 ± 10.6 years, 57 (11-153) months on HD).
Exercise program (performed with elastic bands and ankle cuffs in both lower limbs) was supervised three times a week during 6 months (72 sessions). Patients had their blood drawn in a regular HD day after overnight fasting, before and after 6 months of exercise program. Obestatin, acyl-ghrelin, routine biochemical parameters, quality of life, and anthropometric data were collected and analyzed before and after 6 months.
After 6 months of exercise, obestatin levels reduced [from 3.0 ng/mL (2.3-3.4) to 1.9 ng/mL (0.6-3.4)] and acyl-ghrelin levels increased [from 21.5 pg/mL (1.3-77.7) to 37.2 pg/mL (16.7-94.1)] and the control group presented no significant differences in both plasma levels of hormones. Body composition and physical functional assessed by SF-36 and albumin levels (3.7 ± 0.3 to 3.9 ± 0.2, p < 0.05) improved after exercises.
Six months of resistance exercises contributed to changes in plasma appetite hormones, body composition, and nutritional status in hemodialysis patients.
接受血液透析（HD）的患者体内食欲激素水平发生改变，如酰基胃泌素（促食欲）和肥胖抑制素（抑制食欲），这可能导致厌食。体育锻炼可能会影响这些激素并改善这些患者的食欲。
本研究的目的是评估抗阻运动计划对HD患者食欲激素、身体成分和营养状况的影响。
与对照组的干预性研究。
52名接受常规HD治疗的患者被分为两组：37名患者进行运动（男性占56.7%，年龄45±12.8岁，HD治疗时间57（9 - 192）个月），15名患者作为对照组（男性占66.7%，年龄50±10.6岁，HD治疗时间57（11 - 153）个月）。
运动计划（使用弹力带和脚踝绑带对双下肢进行锻炼）为期6个月，每周监督3次（共72节训练课）。患者在运动计划开始前和6个月后的常规HD日，经过一夜禁食后采血。收集并分析6个月前后的肥胖抑制素、酰基胃泌素、常规生化参数、生活质量和人体测量数据。
运动6个月后，肥胖抑制素水平降低[从3.0纳克/毫升（2.3 - 3.4）降至1.9纳克/毫升（0.6 - 3.4）]，酰基胃泌素水平升高[从21.5皮克/毫升（1.3 - 77.7）升至37.2皮克/毫升（16.7 - 94.1）]，而对照组的两种激素血浆水平均无显著差异。运动后，通过SF - 36评估的身体成分和身体功能以及白蛋白水平（从3.7±0.3升至3.9±0.2，p<0.05）得到改善。
6个月的抗阻运动有助于血液透析患者血浆食欲激素、身体成分和营养状况的改变。
