Soots G, Stankowiak C, Warembourg H, Pol A, Watel A, Prat A, Devulder J P, Dufay C, Moreau D, Noblet D
Ann Chir. 1989;43(8):616-23.
458 patients with a Carpentier-Edwards porcine bioprosthesis (aortic (Ao): 169, mitral (Mi): 289) operated between January 1975 and December 1981, were studied during the first trimester of 1987. Forty seven patients underwent an associated operation. The total follow-up was 3,001 patient-years with a maximum follow-up of 11.4 years and a mean follow-up of 6.5 years. Only 5.6% of patients were lost to follow-up. The patients were aged between 20 and 80 years. The actuarial 9-year survival rate was 69.2 +/- 6.3% for aortic prostheses and 79.6 +/- 3.9% for mitral prostheses. The principal cause of valve failure, appearing with a considerable frequency after 5 years, was primary tissue degeneration which alone represented 67.8% of the causes of valve failure. The rate of absence of valve failure, for all causes combined, was 77.8 +/- 5.9% for the aortic position and 74.9 +/- 4.9% for the mitral position. The actuarial rate of absence of primary tissue degeneration at 9 years was 79.7 +/- 4.1% for aortic prostheses and 75.2 +/- 4.4% for mitral prostheses. The frequency of tissue degeneration decreased with increasing age, representing 2.9%, 1.9% and 1.5% patient-years respectively for the age-groups: 20 to 39 years, 40 to 59 years and 60 to 80 years. However, this difference was not statistically significant. Tissue degeneration was the principal cause for reoperation (n = 59) with an operative mortality of 7.8%.
对1975年1月至1981年12月间接受Carpentier-Edwards猪生物瓣膜置换术的458例患者（主动脉瓣置换术（Ao）：169例，二尖瓣置换术（Mi）：289例）于1987年第一季度进行了研究。47例患者接受了相关手术。总随访时间为3001患者年，最长随访时间为11.4年，平均随访时间为6.5年。仅5.6%的患者失访。患者年龄在20至80岁之间。主动脉瓣人工瓣膜的9年精算生存率为69.2±6.3%，二尖瓣人工瓣膜为79.6±3.9%。瓣膜失效的主要原因是原发性组织退变，5年后出现频率较高，仅原发性组织退变就占瓣膜失效原因的67.8%。所有原因导致的无瓣膜失效发生率，主动脉瓣位为77.8±5.9%，二尖瓣位为74.9±4.9%。主动脉瓣人工瓣膜9年无原发性组织退变的精算发生率为79.7±4.1%，二尖瓣人工瓣膜为75.2±4.4%。组织退变的频率随年龄增长而降低，在20至39岁、40至59岁和60至80岁年龄组中分别为2.9%、1.9%和1.5%患者年。然而，这种差异无统计学意义。组织退变是再次手术（n = 59）的主要原因，手术死亡率为7.8%。
