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[甲状旁腺病理学:常规病理检查的实践要点]

[Pathology of parathyroid glands: Practical aspects for routine pathological investigations].

作者信息

Sheu-Grabellus S-Y, Schmid K W

机构信息

Pathologisches Institut Recklinghausen, Mühlenstr. 31, 45659, Recklinghausen, Deutschland,

出版信息

Pathologe. 2015 May;36(3):229-36. doi: 10.1007/s00292-015-0016-0.

DOI:10.1007/s00292-015-0016-0
PMID:25898935
Abstract

The diagnostic histopathology of parathyroid glands comprises mostly benign diseases associated with primary, secondary and rarely tertiary hyperparathyroidism. Parathyroid adenoma and hyperplasia are the most common diagnoses, whereas parathyroid carcinomas and atypical adenomas are exceptional causes of hyperparathyroidism, the latter being purely a diagnosis by exclusion. This article deals with the major histopathological criteria of the various diagnoses with special emphasis on the clinical manifestation.

摘要

甲状旁腺的诊断性组织病理学主要包括与原发性、继发性以及罕见的三发性甲状旁腺功能亢进相关的良性疾病。甲状旁腺腺瘤和增生是最常见的诊断结果,而甲状旁腺癌和非典型腺瘤是甲状旁腺功能亢进的罕见病因,后者纯粹是一种排除性诊断。本文论述了各种诊断的主要组织病理学标准,并特别强调了临床表现。

相似文献

1
[Pathology of parathyroid glands: Practical aspects for routine pathological investigations].[甲状旁腺病理学:常规病理检查的实践要点]
Pathologe. 2015 May;36(3):229-36. doi: 10.1007/s00292-015-0016-0.
2
Unusual surgical lesions of the parathyroid gland.
Am J Surg. 1969 Nov;118(5):770-8. doi: 10.1016/0002-9610(69)90227-x.
3
The abnormal parathyroid.异常甲状旁腺。
Hum Pathol. 1976 Mar;7(2):127-38. doi: 10.1016/s0046-8177(76)80015-9.
4
[Functional morphology and pathology of the parathyroid glands. Secretion study using tissue culture, electron microscopy, ultrahistochemistry, immunohistochemistry, morphometry and radioimmunoassay].[甲状旁腺的功能形态学与病理学。运用组织培养、电子显微镜检查、超组织化学、免疫组织化学、形态测量学及放射免疫测定法进行的分泌研究]
Veroff Pathol. 1982;119:1-167.
5
Surgical pathology of the parathyroid glands.
Adv Exp Med Biol. 2005;563:1-9. doi: 10.1007/0-387-32025-3_1.
6
Histopathology of the parathyroid glands.甲状旁腺的组织病理学
Acta Otorhinolaryngol Belg. 2001;55(2):95-101.
7
Water-clear cell 'adenoma'. A new entity in the pathology of primary hyperparathyroidism.水样透明细胞“腺瘤”。原发性甲状旁腺功能亢进病理学中的一个新实体。
Arch Pathol Lab Med. 1995 Nov;119(11):996-7.
8
Mast cells in parathyroid glands of hyperparathyroidism.甲状旁腺功能亢进症患者甲状旁腺中的肥大细胞。
J Clin Pathol. 1974 Jan;27(1):31-4. doi: 10.1136/jcp.27.1.31.
9
[Primary hyperparathyroidism. II. Pathology (author's transl)].[原发性甲状旁腺功能亢进症。II. 病理学(作者译)]
MMW Munch Med Wochenschr. 1974 May 3;116(18):961-8.
10
[Primary hyperparathyroidism. Test technics and steps in the diagnosis of parathyroid lesions].
Arch Anat Cytol Pathol. 1983;31(1):49-62.

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The value of ultrasound in combination with 99mTc-MIBI imaging department of ultrasound medicine, for the diagnosis of ectopic parathyroid glands in the thyroid gland in patients with secondary hyperparathyroidism.超声医学科联合 99mTc-MIBI 显像对继发性甲状旁腺功能亢进患者甲状腺异位甲状旁腺的诊断价值。
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Hyperparathyroidism: Pathological Diagnosis and Association with Parathyroid Localization.甲状旁腺功能亢进症:病理诊断及与甲状旁腺定位的关联
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Four Atypical Parathyroid Adenomas Detected by Dual Phase Tc-99m MIBI SPECT.

本文引用的文献

1
[Intraoperative parathyroid hormone determination for primary hyperparathyroidism].[原发性甲状旁腺功能亢进症的术中甲状旁腺激素测定]
Chirurg. 2010 Jul;81(7):636, 638-42. doi: 10.1007/s00104-009-1885-7.
2
Parafibromin and APC as screening markers for malignant potential in atypical parathyroid adenomas.甲状旁腺腺瘤中副神经节素和 APC 作为恶性潜能的筛选标志物。
Endocr Pathol. 2010 Sep;21(3):166-77. doi: 10.1007/s12022-010-9121-z.
3
Parafibromin immunoreactivity: its use as an additional diagnostic marker for parathyroid tumor classification.
通过双时相Tc-99m甲氧基异丁基异腈单光子发射计算机断层扫描检测到的四例非典型甲状旁腺腺瘤
Mol Imaging Radionucl Ther. 2020 Feb 17;29(1):33-36. doi: 10.4274/mirt.galenos.2019.09326.
4
[Surgical treatment of parathyroid carcinoma : Does the initial en bloc resection improve the prognosis?].[甲状旁腺癌的外科治疗:初始整块切除是否能改善预后?]
Chirurg. 2019 Nov;90(11):905-912. doi: 10.1007/s00104-019-1007-0.
5
[Ectopic tissue of the thyroid gland and the parathyroid glands].[甲状腺和甲状旁腺的异位组织]
Pathologe. 2018 Sep;39(5):379-389. doi: 10.1007/s00292-018-0467-1.
6
[Grading of neuroendocrine tumors].[神经内分泌肿瘤的分级]
Pathologe. 2016 Jul;37(4):304-13. doi: 10.1007/s00292-016-0186-4.
副纤维瘤蛋白免疫反应性:其作为甲状旁腺肿瘤分类的额外诊断标志物的应用。
Endocr Relat Cancer. 2007 Jun;14(2):501-12. doi: 10.1677/ERC-07-0021.
4
Parathyroid carcinoma, atypical parathyroid adenoma, or parathyromatosis?甲状旁腺癌、非典型甲状旁腺腺瘤还是甲状旁腺增生症?
Cancer. 2007 Jul 15;110(2):255-64. doi: 10.1002/cncr.22790.
5
Should parafibromin staining replace HRTP2 gene analysis as an additional tool for histologic diagnosis of parathyroid carcinoma?副纤维蛋白染色能否取代HRTP2基因分析,作为甲状旁腺癌组织学诊断的辅助工具?
Eur J Endocrinol. 2007 May;156(5):547-54. doi: 10.1530/EJE-06-0720.
6
Loss of nuclear expression of parafibromin distinguishes parathyroid carcinomas and hyperparathyroidism-jaw tumor (HPT-JT) syndrome-related adenomas from sporadic parathyroid adenomas and hyperplasias.副纤维蛋白核表达缺失可将甲状旁腺癌和与甲状旁腺功能亢进-颌骨肿瘤(HPT-JT)综合征相关的腺瘤与散发性甲状旁腺腺瘤及增生区分开来。
Am J Surg Pathol. 2006 Sep;30(9):1140-9. doi: 10.1097/01.pas.0000209827.39477.4f.
7
Tertiary hyperparathyroidism: histologic patterns of disease and results of parathyroidectomy.三发性甲状旁腺功能亢进症:疾病的组织学模式及甲状旁腺切除术的结果
Arch Surg. 2004 Sep;139(9):974-7. doi: 10.1001/archsurg.139.9.974.
8
Parathyroid neoplasms: clinical, histopathological, and tissue microarray-based molecular analysis.甲状旁腺肿瘤:临床、组织病理学及基于组织芯片的分子分析
Hum Pathol. 2003 Jan;34(1):54-64. doi: 10.1053/hupa.2003.55.
9
HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome.编码 parafibromin 的 HRPT2 在甲状旁腺功能亢进-颌骨肿瘤综合征中发生突变。
Nat Genet. 2002 Dec;32(4):676-80. doi: 10.1038/ng1048. Epub 2002 Nov 18.
10
Oxyphil parathyroid carcinomas: a clinicopathologic and immunohistochemical study of 10 cases.嗜酸性甲状旁腺癌:10例临床病理及免疫组化研究
Am J Surg Pathol. 2002 Mar;26(3):344-9. doi: 10.1097/00000478-200203000-00008.