D'Adamo Christopher R, McMillin Charles R, Chen Kevin W, Lucas Elisabeth K, Berman Brian M
1Department of Family and Community Medicine, School of Medicine, University of Maryland, Baltimore, MD; 2Muscle Systems Consortia, Brooklandville, MD; and 3Timonium, MD.
Med Sci Sports Exerc. 2015 Nov;47(11):2291-8. doi: 10.1249/MSS.0000000000000683.
The rapidly increasing incidence of Lyme disease has become a serious public health problem. Persistent symptoms of Lyme disease occur in over 40% of the 300,000 new cases diagnosed annually in the United States and often include debilitating musculoskeletal pain, fatigue, and poor health-related quality of life. No clinical practice guidelines for Lyme disease currently include resistance exercise partly because of concern over its safety and feasibility in this population. The goal of this pilot study was to evaluate the feasibility and preliminary efficacy of a supervised, low-intensity resistance exercise program in a sample of patients with persistent symptoms of Lyme disease.
An uncontrolled resistance exercise intervention was conducted under the supervision of an exercise professional. Participants performed three exercise sessions per week for 4 wk. Each exercise session consisted of one set of varying repetitions of the leg press, seated row, vertical chest press, standing heel raise, and supine abdominal crunch. Outcomes were assessed at baseline and the end of each week of intervention and included musculoskeletal pain, fatigue, health-related quality of life, vitality, and exercise performance. ANOVA and t-tests were performed to assess changes in the study outcomes.
Eight patients participated in the exercise intervention. All participants successfully completed the intervention, and there were no adverse events related to exercise. Statistically significant improvements (P ≤ 0.05) were noted in exercise performance and in the number of days out of the past 30 d feeling healthy and full of energy (0.6 at baseline and 4.5 at end of intervention).
Although larger and controlled studies are necessary, supervised resistance exercise was feasible and may benefit patients with persistent symptoms of Lyme disease.
莱姆病发病率的迅速上升已成为一个严重的公共卫生问题。在美国，每年确诊的30万例新莱姆病病例中，超过40%会出现持续性症状，这些症状通常包括使人衰弱的肌肉骨骼疼痛、疲劳以及与健康相关的生活质量较差。目前尚无针对莱姆病的临床实践指南将抗阻运动纳入其中，部分原因是担心其在该人群中的安全性和可行性。这项初步研究的目的是评估在一组有莱姆病持续性症状的患者中，进行有监督的低强度抗阻运动计划的可行性和初步疗效。
在一名运动专业人员的监督下进行了一项无对照的抗阻运动干预。参与者每周进行3次运动，共持续4周。每次运动包括一组不同重复次数的腿举、坐姿划船、垂直推胸、站立提踵和仰卧卷腹。在基线和干预的每周末评估结果，包括肌肉骨骼疼痛、疲劳、与健康相关的生活质量、活力和运动表现。进行方差分析和t检验以评估研究结果的变化。
8名患者参与了运动干预。所有参与者均成功完成干预，且未出现与运动相关的不良事件。运动表现以及过去30天中感觉健康且精力充沛的天数（基线时为0.6天，干预结束时为4.5天）有统计学意义的改善（P≤0.05）。
尽管需要更大规模的对照研究，但有监督的抗阻运动是可行的，可能对有莱姆病持续性症状的患者有益。
