Ghose K, Burch A
Department of Geriatric Medicine, Cardiff Royal Infirmary, UK.
Arch Gerontol Geriatr. 1989 Sep-Oct;9(2):115-22. doi: 10.1016/0167-4943(89)90032-0.
Four elderly patients (aged 68-87 yr) with osteoarthritis were treated with 20 mg of tenoxicam (a new non-steroidal anti-inflammatory drug) daily for at least 12 weeks. Tenoxicam did not appear to have any harmful effect on glomerular filtration rate and effective renal plasma flow, as measured by a single intravenous injection of 51Cr-EDTA and 125I-iodohippurate. Plasma concentration of tenoxicam indicated good compliance, and no evidence of unexpected accumulation of tenoxicam in the plasma was observed during 12 weeks of medication.
四名患有骨关节炎的老年患者（年龄68 - 87岁）每天服用20毫克替诺昔康（一种新型非甾体抗炎药），疗程至少12周。通过单次静脉注射51Cr - EDTA和125I - 碘马尿酸盐测量发现，替诺昔康似乎对肾小球滤过率和有效肾血浆流量没有任何有害影响。替诺昔康的血浆浓度表明患者依从性良好，并且在12周的用药期间未观察到替诺昔康在血浆中意外蓄积的迹象。
