Koljonen Virve, Rantanen Matti, Sahi Helka, Mellemkjær Lene, Hansen Bo Terning, Chen Tianhui, Hemminki Kari, Pukkala Eero
a Department of Plastic Surgery , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
b Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research , Helsinki , Finland.
Leuk Lymphoma. 2015;56(12):3315-9. doi: 10.3109/10428194.2015.1040010. Epub 2015 May 26.
The objective of this study was to assess the reciprocal association between non-Hodgkin lymphoma (NHL) and Merkel cell carcinoma (MCC) using the data of four Nordic Cancer Registries. Data for this study were drawn from the Danish, Finnish, Norwegian, and Swedish cancer registries. Standardized incidence ratios (SIRs) for MCC among NHL patients, and for NHL among MCC patients, were calculated. There were 109 838 individuals with NHL and 1411 individuals with MCC, of which 28 had joint occurrence of NHL and MCC. In 18 cases, NHL was diagnosed first, and in 10 cases, MCC was diagnosed first. The SIR for MCC after NHL was 4.34 (95% confidence interval 2.57-6.85). The SIR for NHL after MCC was 3.13 (1.50-5.77). Although the absolute frequency of joint occurrence of MCC and NHL is low, individuals suffering from one of the cancer forms have an increased risk of the other.
本研究的目的是利用四个北欧癌症登记处的数据，评估非霍奇金淋巴瘤（NHL）与默克尔细胞癌（MCC）之间的相互关联。本研究的数据来自丹麦、芬兰、挪威和瑞典的癌症登记处。计算了NHL患者中MCC的标准化发病比（SIRs），以及MCC患者中NHL的标准化发病比。有109838例NHL患者和1411例MCC患者，其中28例同时患有NHL和MCC。在18例中，先诊断出NHL，在10例中，先诊断出MCC。NHL后发生MCC的SIR为4.34（95%置信区间2.57 - 6.85）。MCC后发生NHL的SIR为3.13（1.50 - 5.77）。尽管MCC和NHL同时发生的绝对频率较低，但患有其中一种癌症的个体患另一种癌症的风险会增加。
