Kojima H, Nojima T, Nagashima K, Ono Y, Kudo M, Ishikura M
Department of Pathology, Hokkaido University School of Medicine, Sapporo, Japan.
Arch Pathol Lab Med. 1989 Dec;113(12):1399-401.
Pathologic examination at autopsy of a 74-year-old man with central diabetes insipidus revealed that he had a chronic lymphocytic inflammation limited to the infundibulum, stalk, and posterior lobe of the pituitary gland. No meningitis, sarcoidosis, or granulomas were detected, though there was evidence of chronic pancreatitis. In addition, neuronal loss with gliosis was observed bilaterally in the supraoptic and paraventricular nuclei. The unusual localized inflammatory brain lesion was considered to be responsible for the diabetes insipidus.
一名患有中枢性尿崩症的74岁男性尸检的病理检查显示，他患有局限于垂体漏斗部、柄部和后叶的慢性淋巴细胞性炎症。尽管有慢性胰腺炎的证据，但未检测到脑膜炎、结节病或肉芽肿。此外，视上核和室旁核双侧均观察到神经元丢失伴胶质细胞增生。这种不寻常的局限性脑部炎性病变被认为是导致尿崩症的原因。
