用于肌肉再生的基因和细胞疗法。
Gene and cell therapy for muscle regeneration.
作者信息
Stilhano Roberta Sessa, Martins Leonardo, Ingham Sheila Jean McNeill, Pesquero João Bosco, Huard Johnny
机构信息
Biophysics Department, Federal University of São Paulo - UNIFESP, Rua Mirassol, 207 - Vila Clementino, 04044-010 São Paulo, Brazil.
Department of Orthopaedic Surgery, Federal University of São Paulo, São Paulo, Brazil.
出版信息
Curr Rev Musculoskelet Med. 2015 Jun;8(2):182-187. doi: 10.1007/s12178-015-9268-9.
Abstract
Skeletal muscle injury and healing are multifactorial processes, involving three steps of healing: (1) degeneration and inflammation, (2) regeneration, and (3) fibrosis. Fibrous tissue hinders the muscle's complete recovery and current therapies fail in achieving total muscle recovery. Gene and cell therapy (or both) are potential future treatments for severe muscular injuries. Stem cells' properties associated with growth factors or/and cytokines can improve muscle healing and permit long-term recovery.
摘要
骨骼肌损伤与修复是多因素过程，包括三个修复步骤：(1) 变性与炎症，(2) 再生，以及(3) 纤维化。纤维组织会阻碍肌肉的完全恢复，且目前的治疗方法无法实现肌肉的完全恢复。基因治疗和细胞治疗（或两者结合）是未来治疗严重肌肉损伤的潜在方法。干细胞与生长因子或/和细胞因子相关的特性可改善肌肉修复并实现长期恢复。
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