Price C I, Horton J W, Baxter C R
Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75235-9031.
Arch Surg. 1989 Dec;124(12):1411-4; discussion 1414-5. doi: 10.1001/archsurg.1989.01410120057012.
The local application of antibiotics to treat intraperitoneal contamination has been used with variable results. Liposomes are not rapidly absorbed from the peritoneal cavity, offering a potential delivery system for intraperitoneal antibiotics. The effects of liposome-incorporated antibiotic administration in a fecal peritonitis model were compared with the effects of conventional intraperitoneal and intramuscular antibiotics. Rats were divided into four groups: untreated, intramuscular cefoxitin, intraperitoneal cefoxitin, and intraperitoneal liposome-incorporated cefoxitin. Quantitative blood cultures were drawn at 4 and 24 hours. Liposome delivery of cefoxitin significantly reduced mortality and bacteremia at 4 and 24 hours compared with control subjects and conventional antibiotic groups. Peritoneal abscess formation tended to decrease in the liposome antibiotic group (mean +/- SEM, 6.86 +/- 0.79) compared with the group receiving free intraperitoneal administration of antibiotics (10.33 +/- 1.63). We conclude that liposomal delivery significantly enhances the effectiveness of cefoxitin in this model of peritonitis.
局部应用抗生素治疗腹腔污染的效果不一。脂质体不会很快从腹腔吸收，为腹腔内抗生素提供了一种潜在的递送系统。将脂质体包裹抗生素给药在粪性腹膜炎模型中的效果与传统腹腔内和肌肉注射抗生素的效果进行了比较。大鼠被分为四组：未治疗组、肌肉注射头孢西丁组、腹腔注射头孢西丁组和腹腔注射脂质体包裹头孢西丁组。在4小时和24小时采集定量血培养样本。与对照组和传统抗生素组相比，脂质体递送头孢西丁在4小时和24小时时显著降低了死亡率和菌血症。与接受游离腹腔内抗生素给药的组（10.33±1.63）相比，脂质体抗生素组的腹腔脓肿形成有减少趋势（均值±标准误，6.86±0.79）。我们得出结论，在该腹膜炎模型中，脂质体递送显著提高了头孢西丁的疗效。
