1 Tel Aviv University, Israel.
2 The Edmond and Lily Safra Children's Hospital, Tel Hashomer, Israel.
J Atten Disord. 2019 Jan;23(2):135-139. doi: 10.1177/1087054715580844. Epub 2015 Apr 21.
To examine whether a familial tendency exists in clinical response to methylphenidate.
Nineteen pairs of siblings or parent-child stimulant-naive individuals with ADHD were prescribed methylphenidate-immediate release, and were comprehensively evaluated at baseline, Week 2, and Week 4, using the ADHD Rating Scale IV, Clinical Global Impression Scale, and the Barkley Side Effects Rating Scale.
We found significant intraclass correlations in family member response to methylphenidate-immediate release and side effect profile, including emotional symptoms and loss of appetite and weight.
Family history of response to methylphenidate should be taken into account when treating ADHD.
研究哌醋甲酯治疗的临床反应是否存在家族倾向。
19 对 ADHD 未用药的兄弟姐妹或亲子被处方哌醋甲酯速释剂，并在基线、第 2 周和第 4 周使用 ADHD 评定量表-IV、临床总体印象量表和 Barkley 副作用评定量表进行全面评估。
我们发现哌醋甲酯速释剂治疗反应和副作用特征（包括情绪症状、食欲不振和体重减轻）在家庭成员之间存在显著的组内相关性。
在治疗 ADHD 时，应考虑家族对哌醋甲酯的反应史。
