High Familial Correlation in Methylphenidate Response and Side Effect Profile.

OBJECTIVE

To examine whether a familial tendency exists in clinical response to methylphenidate.

METHOD

Nineteen pairs of siblings or parent-child stimulant-naive individuals with ADHD were prescribed methylphenidate-immediate release, and were comprehensively evaluated at baseline, Week 2, and Week 4, using the ADHD Rating Scale IV, Clinical Global Impression Scale, and the Barkley Side Effects Rating Scale.

RESULTS

We found significant intraclass correlations in family member response to methylphenidate-immediate release and side effect profile, including emotional symptoms and loss of appetite and weight.

CONCLUSION

Family history of response to methylphenidate should be taken into account when treating ADHD.