[A clinical trial of microcomputer software for calculation of aminophylline dosages].

I made microcomputer software for the pharmacokinetic calculation of appropriate administration doses of aminophylline for the treatment of status asthmaticus. It consists of three programs for determination of initial doses, four for determination of maintenance doses, and four for calculation of the pharmacokinetics parameters (Vd, Ke, CL, T1/2). The parameters were estimated 376 times during 151 attacks in 84 patients with bronchial asthma. Vd, Ke, and CL were calculated as below, and the wide variation in the values suggests that individual programs for theophylline therapy should be made for each patient. I concluded that these microcomputer programs were useful in creating an individual administration program. Distribution volume (Vd): 385 +/- 106 ml/kg (n = 115) Elimination rate constant (Ke): 0.155 +/- 0.0878/h (n = 176) Clearance (CL): 61.8 +/- 14.3 ml/kg.h (n = 85)