Matsuda Mayu, Behrend Ellen N, Kemppainen Robert, Refsal Kent, Johnson Aime, Lee Hollie
Departments of Clinical Sciences (Matsuda, Behrend, Johnson, Lee), College of Veterinary Medicine, Auburn University, Auburn, ALAnatomy, Physiology, and Pharmacology (Kemppainen), College of Veterinary Medicine, Auburn University, Auburn, ALDepartment of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI (Refsal).
Departments of Clinical Sciences (Matsuda, Behrend, Johnson, Lee), College of Veterinary Medicine, Auburn University, Auburn, ALAnatomy, Physiology, and Pharmacology (Kemppainen), College of Veterinary Medicine, Auburn University, Auburn, ALDepartment of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI (Refsal)
J Vet Diagn Invest. 2015 May;27(3):361-8. doi: 10.1177/1040638715583530. Epub 2015 Apr 21.
Primary hyperaldosteronism is an increasingly recognized syndrome in cats, and diagnosis can be difficult. A potential diagnostic method has been reported, utilizing oral fludrocortisone administered twice daily for 4 days followed by collection of urine. In the current study, we sought to determine if blood sampling and a shorter dosing period would provide a possible means to test for primary hyperaldosteronism. Also, cortisol concentrations were measured to assess the potential of fludrocortisone to act as a glucocorticoid in cats. In phase I, 8 healthy laboratory cats were studied in a placebo-controlled, crossover design. Serum aldosterone and cortisol concentrations were measured before and on the second, third, and fourth day of treatment and compared within groups. In phase II, based on the results obtained in phase I, 8 healthy client-owned cats were administered 3 doses of fludrocortisone or placebo. Serum aldosterone and cortisol concentrations were compared before and after treatment within groups. In both phases, serum aldosterone and cortisol concentrations were significantly suppressed in fludrocortisone-treated cats. Thus, it was determined that oral administration of fludrocortisone causes suppression of serum aldosterone in healthy adult cats after only 3 doses. Further research is needed to determine the effects of oral fludrocortisone in cats with primary hyperaldosteronism and cats with other disorders causing hypertension and/or hypokalemia to determine if this protocol can be used as a tool for the definitive diagnosis of primary hyperaldosteronism.
原发性醛固酮增多症在猫中是一种越来越被认识到的综合征，诊断可能具有挑战性。已报道了一种潜在的诊断方法，即每天口服氟氢可的松两次，持续4天，然后收集尿液。在本研究中，我们试图确定采血和更短的给药期是否能提供一种检测原发性醛固酮增多症的可能方法。此外，还测量了皮质醇浓度，以评估氟氢可的松在猫体内作为糖皮质激素的潜力。在第一阶段，采用安慰剂对照、交叉设计对8只健康的实验猫进行了研究。在治疗前以及治疗的第二天、第三天和第四天测量血清醛固酮和皮质醇浓度，并在组内进行比较。在第二阶段，根据第一阶段获得的结果，对8只健康的客户拥有的猫给予3剂氟氢可的松或安慰剂。在组内比较治疗前后的血清醛固酮和皮质醇浓度。在两个阶段中，氟氢可的松治疗的猫的血清醛固酮和皮质醇浓度均被显著抑制。因此，确定仅口服3剂氟氢可的松就能使健康成年猫的血清醛固酮受到抑制。需要进一步研究以确定口服氟氢可的松对患有原发性醛固酮增多症的猫以及患有其他导致高血压和/或低钾血症的疾病的猫的影响，以确定该方案是否可作为原发性醛固酮增多症确诊的工具。
