Matsura Tatsuya
Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8503, Japan.
Yonago Acta Med. 2014 Dec;57(4):119-27. Epub 2014 Dec 26.
Recent development of analytical methods for lipid hydroperoxides and preparation of highly pure lipid hydroperoxides have revealed the important new pathophysiological roles of oxidized phospholipids. Generation of reactive oxygen species and subsequent oxidative stress leads to random oxidation of membrane phospholipids. However, recent studies have reported that anionic phospholipid molecules such as phosphatidylserine (PS) and cardiolipin are preferentially oxidized during apoptosis, resulting in efficient apoptosis execution and apoptotic cell clearance by phagocytes. This review is exclusively focused on selective production of oxidized PS (oxPS) during apoptosis as well as the novel roles of oxPS under pathophysiological conditions.
脂质氢过氧化物分析方法的最新进展以及高纯度脂质氢过氧化物的制备揭示了氧化磷脂重要的新病理生理作用。活性氧的产生及随后的氧化应激会导致膜磷脂的随机氧化。然而，最近的研究报道，在细胞凋亡过程中，阴离子磷脂分子如磷脂酰丝氨酸（PS）和心磷脂会优先被氧化，从而导致细胞凋亡的有效执行以及吞噬细胞对凋亡细胞的清除。本综述专门聚焦于细胞凋亡过程中氧化型PS（oxPS）的选择性产生以及oxPS在病理生理条件下的新作用。
