国家肺癌筛查试验的结果：我们现在处于什么阶段？
Results of the national lung cancer screening trial: where are we now?
作者信息
Chudgar Neel P, Bucciarelli Peter R, Jeffries Elizabeth M, Rizk Nabil P, Park Bernard J, Adusumilli Prasad S, Jones David R
机构信息
Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
出版信息
Thorac Surg Clin. 2015 May;25(2):145-53. doi: 10.1016/j.thorsurg.2014.11.002. Epub 2015 Feb 2.
Abstract
The National Lung Screening Trial was a large, multicenter, randomized controlled trial published in 2011. It found that annual screening with low-dose CT (LDCT) in a high-risk population was associated with a 20% reduction in lung cancer-specific mortality compared with conventional chest radiography. Several leading professional organizations have since put forth lung cancer screening guidelines that include the use of LDCT, largely on the basis of this study. Broad adoption of these screening recommendations, however, remains a challenge.
摘要
国家肺癌筛查试验是一项大型、多中心、随机对照试验，于2011年发表。该试验发现，与传统胸部X光检查相比，在高危人群中每年进行低剂量CT（LDCT）筛查可使肺癌特异性死亡率降低20%。此后，几个主要的专业组织提出了肺癌筛查指南，其中包括使用LDCT，这主要是基于这项研究。然而，广泛采用这些筛查建议仍然是一项挑战。
相似文献
1
Results of the national lung cancer screening trial: where are we now?国家肺癌筛查试验的结果：我们现在处于什么阶段？
Thorac Surg Clin. 2015 May;25(2):145-53. doi: 10.1016/j.thorsurg.2014.11.002. Epub 2015 Feb 2.
2
Lung Cancer Screening: Computed Tomography Radiation and Protocols.肺癌筛查：计算机断层扫描辐射与方案
J Thorac Imaging. 2015 Sep;30(5):283-9. doi: 10.1097/RTI.0000000000000150.
3
Lung Cancer Screening With Low-Dose CT in the United States.美国低剂量CT肺癌筛查
J Am Coll Radiol. 2015 Dec;12(12 Pt B):1395-402. doi: 10.1016/j.jacr.2015.09.016.
4
The evidence for low-dose CT screening of lung cancer.低剂量CT筛查肺癌的证据。
Clin Imaging. 2016 Mar-Apr;40(2):288-95. doi: 10.1016/j.clinimag.2015.07.001. Epub 2015 Jul 17.
5
Performance of the cancer risk management model lung cancer screening module.肺癌筛查模块的癌症风险管理模型性能。
Health Rep. 2015 May;26(5):11-8.
6
Lung cancer screening with low-dose helical CT: results from the National Lung Screening Trial (NLST).低剂量螺旋CT肺癌筛查：国家肺癌筛查试验（NLST）结果
J Med Screen. 2011;18(3):109-11. doi: 10.1258/jms.2011.011055.
7
Low-dose CT for lung cancer screening: opportunities and challenges.低剂量 CT 肺癌筛查：机遇与挑战。
Front Med. 2018 Feb;12(1):116-121. doi: 10.1007/s11684-017-0600-1. Epub 2017 Dec 7.
8
Results of initial low-dose computed tomographic screening for lung cancer.肺癌初始低剂量计算机断层扫描筛查结果。
N Engl J Med. 2013 May 23;368(21):1980-91. doi: 10.1056/NEJMoa1209120.
9
Low-dose computed tomography screening for lung cancer: results of the first screening round.低剂量计算机断层扫描筛查肺癌：首轮筛查结果。
J Comp Eff Res. 2013 Sep;2(5):433-6. doi: 10.2217/cer.13.57.
10
Preliminary Results of Lung Cancer Screening in a Socioeconomically Disadvantaged Population.肺癌筛查在社会经济弱势群体中的初步结果。
AJR Am J Roentgenol. 2018 Mar;210(3):489-496. doi: 10.2214/AJR.17.18853. Epub 2017 Nov 22.
引用本文的文献
1
Next generation performance status: digital health technologies across the lung cancer continuum.下一代性能状态：贯穿肺癌全程的数字健康技术
Front Digit Health. 2025 Jul 10;7:1558180. doi: 10.3389/fdgth.2025.1558180. eCollection 2025.
2
Lung Cancer-Epidemiology, Pathogenesis, Treatment and Molecular Aspect (Review of Literature).肺癌——流行病学、发病机制、治疗及分子层面（文献综述）
Int J Mol Sci. 2025 Feb 26;26(5):2049. doi: 10.3390/ijms26052049.
3
Economic Evaluation of a Novel Lung Cancer Diagnostic in a Population of Patients with a Positive Low-Dose Computed Tomography Result.低剂量计算机断层扫描结果呈阳性的患者群体中一种新型肺癌诊断方法的经济学评价
J Health Econ Outcomes Res. 2024 Sep 17;11(2):74-79. doi: 10.36469/001c.121512. eCollection 2024.
4
Vascular Biomarkers for Pulmonary Nodule Malignancy: Arteries vs. Veins.用于肺结节恶性肿瘤的血管生物标志物：动脉与静脉
Cancers (Basel). 2024 Sep 26;16(19):3274. doi: 10.3390/cancers16193274.
5
The Effect of COVID-19 on Lung Cancer Screening.新冠病毒病对肺癌筛查的影响。
Cureus. 2024 Sep 9;16(9):e68986. doi: 10.7759/cureus.68986. eCollection 2024 Sep.
6
The cognitive and perceptual processes that affect observer performance in lung cancer detection: a scoping review.影响肺癌检测中观察者表现的认知和感知过程：范围综述。
J Med Radiat Sci. 2021 Jun;68(2):175-185. doi: 10.1002/jmrs.456. Epub 2021 Feb 8.
7
Diagnostic accuracy of magnetic resonance imaging for the detection of pulmonary nodules simulated in a dedicated porcine chest phantom.专用猪胸部仿体模拟肺结节的磁共振成像检测的诊断准确性。
PLoS One. 2020 Dec 23;15(12):e0244382. doi: 10.1371/journal.pone.0244382. eCollection 2020.
8
Downregulated microRNA-140-5p expression regulates apoptosis, migration and invasion of lung cancer cells by targeting zinc finger protein 800.下调的微小RNA-140-5p表达通过靶向锌指蛋白800调控肺癌细胞的凋亡、迁移和侵袭。
Oncol Lett. 2020 Dec;20(6):390. doi: 10.3892/ol.2020.12253. Epub 2020 Oct 29.
9
Non-invasive Detection of Exosomal MicroRNAs via Tethered Cationic Lipoplex Nanoparticles (tCLN) Biochip for Lung Cancer Early Detection.通过用于肺癌早期检测的 tethered 阳离子脂质体纳米颗粒（tCLN）生物芯片对外泌体微小核糖核酸进行无创检测。
Front Genet. 2020 Mar 20;11:258. doi: 10.3389/fgene.2020.00258. eCollection 2020.
10
Lobar or sublobar resections are safe procedures for management of early lung cancer.肺叶或肺段切除术是早期肺癌治疗的安全手术。
Ann Transl Med. 2019 Jul;7(Suppl 3):S107. doi: 10.21037/atm.2019.05.13.
本文引用的文献
1
Low-dose spiral CT screening and evaluation of the solitary pulmonary nodule.低剂量螺旋 CT 筛查及孤立性肺结节评估。
Oncology (Williston Park). 2014 May;28(5):441-6.
2
Balancing the benefits and harms of low-dose computed tomography screening for lung cancer: Medicare's options for coverage.权衡低剂量计算机断层扫描肺癌筛查的利弊：医疗保险的覆盖选项。
Ann Intern Med. 2014 Sep 16;161(6):445-6. doi: 10.7326/M14-1352.
3
Cancer treatment and survivorship statistics, 2014.癌症治疗和生存统计，2014 年。
CA Cancer J Clin. 2014 Jul-Aug;64(4):252-71. doi: 10.3322/caac.21235. Epub 2014 Jun 1.
4
In the clinic. Screening for colorectal cancer.在诊所。进行结直肠癌筛查。
Ann Intern Med. 2014 May 6;160(9). doi: 10.7326/0003-4819-160-9-201405060-01005.
5
A systematic assessment of benefits and risks to guide breast cancer screening decisions.系统评估获益与风险以指导乳腺癌筛查决策。
JAMA. 2014 Apr 2;311(13):1327-35. doi: 10.1001/jama.2014.1398.
6
Cancer statistics, 2014.癌症统计数据，2014 年。
CA Cancer J Clin. 2014 Jan-Feb;64(1):9-29. doi: 10.3322/caac.21208. Epub 2014 Jan 7.
7
Raising the bar for the U.S. Preventive Services Task Force.提高美国预防服务工作组的标准。
Ann Intern Med. 2014 Mar 4;160(5):365-6. doi: 10.7326/M13-2926.
8
Screening for lung cancer: moving into a new era.肺癌筛查：步入新时代。
Ann Intern Med. 2014 Mar 4;160(5):363-4. doi: 10.7326/M13-2904.
9
Benefits and harms of computed tomography lung cancer screening strategies: a comparative modeling study for the U.S. Preventive Services Task Force.计算机断层扫描肺癌筛查策略的利弊：美国预防服务工作组的比较建模研究。
Ann Intern Med. 2014 Mar 4;160(5):311-20. doi: 10.7326/M13-2316.
10
Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement.肺癌筛查：美国预防服务工作组推荐声明。
Ann Intern Med. 2014 Mar 4;160(5):330-8. doi: 10.7326/M13-2771.
Zotero 插件