曲匹地尔片的生物利用度。
Bioavailability of trapidil tablets.
作者信息
Weiss M, Sziegoleit W, Pönicke K, Schobess M, Fahr A, Mest H J
机构信息
Department of Pharmacology and Toxicology, Martin Luther University, Halle, German Democratic Republic.
出版信息
Arzneimittelforschung. 1989 Sep;39(9):1137-8.
PMID:2590264
Abstract
Trapidil was given orally (200 mg, Rocornal dragees 100 mg) and intravenously (100 mg) to 12 healthy volunteers. Serum samples were analyzed for trapidil by HPLC. Complete bioavailability was obtained and a mean absorption time of 66.4 min was calculated using the method of curve moments.
摘要
对12名健康志愿者口服给予曲匹地尔（200毫克，含100毫克曲匹地尔的Rocornal糖衣丸）和静脉注射给予曲匹地尔（100毫克）。采用高效液相色谱法分析血清样本中的曲匹地尔。获得了完整的生物利用度，并使用曲线矩法计算出平均吸收时间为66.4分钟。
Zotero 插件