Ginat Daniel Thomas, Johnson Daniel N, Cipriani Nicole A
Department of Radiology, Pritzker School of Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA.
Department of Pathology, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.
Head Neck Pathol. 2016 Jun;10(2):209-12. doi: 10.1007/s12105-015-0629-x. Epub 2015 Apr 24.
Langerhans cell histiocytosis involving the temporal bone region is uncommon and can resemble malignant neoplasms on imaging due to high cellularity. Although recognizing the presence of sharp margins with beveled-edges can be helpful, tissue sampling is often necessary for confirming the diagnosis. Cytology classically demonstrates kidney-bean shaped nuclei within the Langerhans cells and immunohistochemical staining is positive for S-100, peanut agglutinin (PNA), MHC class II, CD1a, and Langerin (CD 207). These features are exemplified in this sine qua non radiology-pathology correlation article.
累及颞骨区域的朗格汉斯细胞组织细胞增多症并不常见，由于细胞密度高，在影像学上可类似恶性肿瘤。尽管认识到存在带斜边的清晰边缘可能有所帮助，但通常需要组织取样来确诊。细胞学检查经典表现为朗格汉斯细胞内呈蚕豆形的细胞核，免疫组织化学染色对S-100、花生凝集素（PNA）、MHC II类分子、CD1a和朗格素（CD 207）呈阳性。这些特征在这篇必不可少的放射学与病理学相关性文章中得到了例证。
