Wnting out ocular neovascularization: using nanoparticle delivery of very-low density lipoprotein receptor extracellular domain as Wnt pathway inhibitor in the retina.
作者信息
Busik Julia V, Grant Maria B
机构信息
From the Department of Physiology, Michigan State University, East Lansing (J.V.B.); and Departments of Ophthalmology and Cellular and Integrative Physiology, Indiana University, Indianapolis (M.B.G.).
出版信息
Arterioscler Thromb Vasc Biol. 2015 May;35(5):1046-7. doi: 10.1161/ATVBAHA.115.305395.
Abstract
摘要
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2
Receptor heterodimerization as a novel mechanism for the regulation of Wnt/β-catenin signaling.受体异二聚化作为Wnt/β-连环蛋白信号调控的一种新机制。
J Cell Sci. 2014 Nov 15;127(Pt 22):4857-69. doi: 10.1242/jcs.149302. Epub 2014 Sep 30.
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Antiangiogenic therapy with anti-vascular endothelial growth factor modalities for diabetic macular oedema.采用抗血管内皮生长因子疗法治疗糖尿病性黄斑水肿的抗血管生成治疗
Cochrane Database Syst Rev. 2012 Dec 12;12:CD007419. doi: 10.1002/14651858.CD007419.pub3.
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Wnt signaling mediates pathological vascular growth in proliferative retinopathy.Wnt 信号通路介导增生性视网膜病变中的病理性血管生长。
Circulation. 2011 Oct 25;124(17):1871-81. doi: 10.1161/CIRCULATIONAHA.111.040337. Epub 2011 Oct 3.
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Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models.Wnt 通路的激活在人类和动物模型的糖尿病性视网膜病变中起着致病作用。
Am J Pathol. 2009 Dec;175(6):2676-85. doi: 10.2353/ajpath.2009.080945. Epub 2009 Nov 5.
6
Antiangiogenic therapy with anti-vascular endothelial growth factor modalities for diabetic macular oedema.采用抗血管内皮生长因子疗法治疗糖尿病性黄斑水肿的抗血管生成治疗
Cochrane Database Syst Rev. 2009 Oct 7(4):CD007419. doi: 10.1002/14651858.CD007419.pub2.
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Very low density lipoprotein receptor, a negative regulator of the wnt signaling pathway and choroidal neovascularization.极低密度脂蛋白受体，一种Wnt信号通路和脉络膜新生血管形成的负调节因子。
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Biochemical alterations in the retinas of very low-density lipoprotein receptor knockout mice: an animal model of retinal angiomatous proliferation.极低密度脂蛋白受体基因敲除小鼠视网膜的生化改变：视网膜血管瘤样增生的动物模型
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