甲状腺乳头状癌与2型多发性内分泌腺瘤病
Papillary thyroid carcinoma and multiple endocrine neoplasia type 2.
作者信息
Febrero B, Rodríguez J M, Ríos A, Portillo P, Parrilla P
机构信息
Service of General Surgery, Unit of Endocrine Surgery, Instituto Murciano de Investigaciones Biomédicas (IMIB), Virgen de la Arrixaca Clinical Universitary Hospital, Crta./Madrid-Cartagena, s/n. El Palmar, 30120, Murcia, Spain.
Service of Endocrinology, Virgen de la Arrixaca Clinical Universitary Hospital, Crta./Madrid-Cartagena, s/n. El Palmar, 30120, Murcia, Spain.
出版信息
J Endocrinol Invest. 2015 Nov;38(11):1233-7. doi: 10.1007/s40618-015-0290-y. Epub 2015 Apr 23.
INTRODUCTION
Papillary thyroid carcinoma (PTC) is exceptional in MEN 2.
RESULTS
The analysis in 135 patients revealed two PTC, without C-cell pathology; both being positive for V804M mutation (RET proto-oncogene).
CONCLUSIONS
Few data are available about PTC in MEN 2, and without C-cell pathology is even less common. More studies are needed to correlate genetics and histology, and even for assessing PTC as only manifestation of MEN 2.
引言
甲状腺乳头状癌（PTC）在MEN 2中较为罕见。
结果
对135例患者的分析发现了2例PTC，无C细胞病变；两者均为RET原癌基因V804M突变阳性。
结论
关于MEN 2中PTC的数据较少，且无C细胞病变的情况更为罕见。需要更多研究来关联遗传学和组织学，甚至用于评估PTC是否为MEN 2的唯一表现形式。
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