盘基网柄菌细胞悬液中的pH振荡：它们与环磷酸腺苷信号的关系。

PH oscillations in cell suspensions of Dictyostelium discoideum: their relation to cyclic-amp signals.

作者信息

Malchow D, Nanjundiah V, Gerisch G

出版信息

J Cell Sci. 1978 Apr;30:319-30. doi: 10.1242/jcs.30.1.319.

DOI:10.1242/jcs.30.1.319

Abstract

Cells of Dictyostelium discoideum known to release cyclic AMP (cAMP) rhythmically in the form of pulses, change with the same period of about 8 min the pH of their medium. The pH is used here as an indicator to investigate the effect of externally added cAMP pulses on the oscillations. Both a temporary increase in amplitude and a permanent phase shift can be induced. The phase-response curve indicates that the period can be increased and decreased by rhythmic stimulation with cAMP pulses.

摘要

已知盘基网柄菌细胞会以脉冲形式有节奏地释放环磷酸腺苷（cAMP），其培养基的pH值会以约8分钟的相同周期发生变化。在此，pH值用作指标来研究外部添加的cAMP脉冲对振荡的影响。既可以诱导振幅暂时增加，也可以诱导永久性相位偏移。相位响应曲线表明，通过cAMP脉冲的节律性刺激可以增加和减少周期。