帕金森病患者可能的快动眼睡眠行为障碍的纵向评估。
Longitudinal assessment of probable rapid eye movement sleep behaviour disorder in Parkinson's disease.
机构信息
Department of Neurology, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway.
Department of Neurology, Oslo University Hospital, Oslo, Norway.
出版信息
Eur J Neurol. 2015 Aug;22(8):1242-4. doi: 10.1111/ene.12723. Epub 2015 Apr 22.
BACKGROUND AND PURPOSE
Rapid eye movement (REM) sleep behaviour disorder (RBD) is frequently present in patients with Parkinson's disease (PD) and may have prognostic implications. There are few longitudinal studies of RBD in patients with PD. Our aim was to investigate whether RBD was a persistent feature in a follow-up study of 107 patients with PD.
METHODS
After a mean follow-up time of 3 years, 96 patients were available for reassessment. Probable RBD (pRBD) was diagnosed by the REM sleep behaviour disorder screening questionnaire.
RESULTS
At follow-up, pRBD was found in 49% of the patients, versus 38% at baseline. The pRBD status remained unchanged in three-quarters of the patients, whilst 17% had new pRBD symptoms. Disease duration was longer in the pRBD group, 9.4 vs. 7.6 years (P = 0.02).
CONCLUSIONS
Probable RBD is a persistent feature in PD and probably increases over time.
背景与目的
快速眼动（REM）睡眠行为障碍（RBD）在帕金森病（PD）患者中经常出现，并可能具有预后意义。关于 PD 患者 RBD 的纵向研究较少。我们的目的是在对 107 例 PD 患者的随访研究中，探讨 RBD 是否是一个持续性特征。
方法
平均随访 3 年后，96 例患者可进行重新评估。使用 REM 睡眠行为障碍筛查问卷诊断可能的 RBD（pRBD）。
结果
随访时，49%的患者存在 pRBD，而基线时为 38%。pRBD 状态在四分之三的患者中保持不变，而 17%的患者出现新的 pRBD 症状。pRBD 组的病程更长，为 9.4 年 vs. 7.6 年（P=0.02）。
结论
在 PD 中，pRBD 是一个持续性特征，并且可能随着时间的推移而增加。
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