评估长期居住在高氡及其衰变产物暴露环境中的儿童外周血淋巴细胞中的染色体畸变水平。

Assessing the level of chromosome aberrations in peripheral blood lymphocytes in long-term resident children under conditions of high exposure to radon and its decay products.

作者信息

Druzhinin Vladimir G, Sinitsky Maxim Yu, Larionov Aleksey V, Volobaev Valentin P, Minina Varvara I, Golovina Tatiana A

机构信息

Department of Genetics, Biology Faculty, Kemerovo State University, Krasnaya St. 6, Kemerovo 650043, Russian Federation and Institute of Human Ecology of SB RAS, Leningradsky Ave 10, Kemerovo 650065, Russian Federation.

Department of Genetics, Biology Faculty, Kemerovo State University, Krasnaya St. 6, Kemerovo 650043, Russian Federation and

出版信息

Mutagenesis. 2015 Sep;30(5):677-83. doi: 10.1093/mutage/gev029. Epub 2015 Apr 22.

DOI:10.1093/mutage/gev029

PMID:25904585

Abstract

In this study, the frequency and spectrum of chromosomal aberrations were analysed in samples of peripheral blood from 372 (mean age = 12.24 ± 2.60 years old) long-term resident children in a boarding school (Tashtagol city, Kemerovo Region, Russian Federation) under conditions of high exposure to radon and its decay products. As a control group, we used blood samples from people living in Zarubino village (Kemerovo Region, Russian Federation). We discovered that the average frequencies of single and double fragments, chromosomal exchanges, total number of aberrations, chromatid type, chromosome type and all types of aberrations were significantly increased in the exposed group. This is evidence of considerable genotoxicity to children living under conditions of high exposure to radon compared to children living under ecological conditions without increased radon radiation.

摘要

在本研究中，对来自俄罗斯联邦克麦罗沃州塔什塔戈尔市一所寄宿学校的372名长期住校儿童（平均年龄 = 12.24 ± 2.60岁）的外周血样本进行了染色体畸变频率和谱分析，这些儿童处于高氡及其衰变产物暴露环境中。作为对照组，我们使用了来自俄罗斯联邦克麦罗沃州扎鲁比诺村居民的血样。我们发现，暴露组中单个和双个片段、染色体交换、畸变总数、染色单体型、染色体型以及所有类型畸变的平均频率均显著增加。这证明，与生活在无氡辐射增加的生态环境中的儿童相比，处于高氡暴露环境中的儿童具有相当大的遗传毒性。