Ogunjimi Benson, Hens Niel, Pebody Richard, Jansens Hilde, Seale Holly, Quinlivan Mark, Theeten Heidi, Goossens Herman, Breuer Judy, Beutels Philippe
a Centre for Health Economics Research & Modeling Infectious Diseases (CHERMID); Vaccine & Infectious Disease Institute (VAXINFECTIO); University of Antwerp ; Antwerp , Belgium.
Hum Vaccin Immunother. 2015;11(6):1394-9. doi: 10.1080/21645515.2015.1037999.
Herpes zoster (HZ) is caused by VZV reactivation that is facilitated by a declined immunity against varicella-zoster virus (VZV), but also occurs in immunocompetent individuals. Cytomegalovirus (CMV) infection is associated with immunosenescence meaning that VZV-specific T-cells could be less responsive. This study aimed to determine whether CMV infection could be a risk factor for the development of HZ. CMV IgG serostatus was determined in stored serum samples from previously prospectively recruited ambulatory adult HZ patients in the UK (N = 223) in order to compare the results with those from UK population samples (N = 1545) by means of a logistic regression (controlling for age and gender). Furthermore, we compared the UK population CMV seroprevalence with those from population samples from other countries (from Belgium (N1 = 1741, N2 = 576), USA (N = 5572) and Australia (N = 2080)). Furthermore, CMV IgG titers could be compared between UK HZ patients and Belgium N2 population samples because the same experimental set-up for analysis was used. We found UK ambulatory HZ patients to have a higher CMV seroprevalence than UK population samples (OR 1.56 [1.11 2.19]). CMV IgG seropositivity was a significant risk factor for HZ in the UK (OR 3.06 [1.32 7.04]. Furthermore, high CMV IgG titers (exceeding the upper threshold) were less abundant in CMV-seropositive Belgian N2 population samples than in CMV-seropositive UK HZ patients (OR 0.51 [0.31 0.82]. We found CMV-seroprevalence to increase faster with age in the UK than in other countries (P < 0.05). We conclude that CMV IgG seropositivity is associated with HZ. This finding could add to the growing list of risk factors for HZ.
带状疱疹（HZ）由水痘-带状疱疹病毒（VZV）再激活引起，免疫力下降易导致其对水痘-带状疱疹病毒（VZV）的抵抗力降低，但免疫功能正常的个体也会发病。巨细胞病毒（CMV）感染与免疫衰老相关，这意味着VZV特异性T细胞的反应性可能较低。本研究旨在确定CMV感染是否可能是HZ发病的危险因素。通过对英国之前前瞻性招募的非卧床成年HZ患者（N = 223）的储存血清样本进行CMV IgG血清学状态检测，以便通过逻辑回归（控制年龄和性别）将结果与英国人群样本（N = 1545）的结果进行比较。此外，我们还将英国人群的CMV血清阳性率与其他国家人群样本（来自比利时（N1 = 1741，N2 = 576）、美国（N = 5572）和澳大利亚（N = 2080））的进行了比较。此外，由于使用了相同的实验分析设置，因此可以比较英国HZ患者和比利时N2人群样本之间的CMV IgG滴度。我们发现英国非卧床HZ患者的CMV血清阳性率高于英国人群样本（比值比1.56 [1.11 2.19]）。在英国，CMV IgG血清阳性是HZ的一个重要危险因素（比值比3.06 [1.32 7.04]）。此外，CMV血清阳性的比利时N2人群样本中高CMV IgG滴度（超过上限阈值）的比例低于CMV血清阳性的英国HZ患者（比值比0.51 [0.31 0.82]）。我们发现英国的CMV血清阳性率随年龄增长的速度比其他国家更快（P < 0.05）。我们得出结论，CMV IgG血清阳性与HZ相关。这一发现可能会增加HZ危险因素的清单。
