State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China.
Org Lett. 2015 May 15;17(10):2322-5. doi: 10.1021/acs.orglett.5b00730. Epub 2015 Apr 23.
The title reaction proceeds with acetylenic triflones and isocyanides under mild conditions using copper as a catalyst. This transformation provides an efficient access to (E)-N-alkyl trifluoromethyl alkynyl ketoimines, which are useful building blocks for the synthesis of CF3-containing N-heterocycles, propargylamines, etc.
标题反应在温和条件下使用铜作为催化剂，通过炔三氟甲磺酸酯和异氰进行。这种转化为（E）-N-烷基三氟甲基炔基酮亚胺提供了一种有效的方法，这些酮亚胺是合成含 CF3 的 N-杂环、炔丙胺等的有用砌块。
