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电子近距离放射治疗源周围水的吸收剂量测量。两种剂量测定系统的比较:甲酸锂电子顺磁共振剂量计和放射变色EBT2薄膜。

Measurement of absorbed dose to water around an electronic brachytherapy source. Comparison of two dosimetry systems: lithium formate EPR dosimeters and radiochromic EBT2 film.

作者信息

Adolfsson Emelie, White Shane, Landry Guillaume, Lund Eva, Gustafsson Håkan, Verhaegen Frank, Reniers Brigitte, Carlsson Tedgren Åsa, Carlsson Gudrun Alm

机构信息

Radiation Physics, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.

出版信息

Phys Med Biol. 2015 May 7;60(9):3869-82. doi: 10.1088/0031-9155/60/9/3869. Epub 2015 Apr 23.

Abstract

Interest in high dose rate (HDR) electronic brachytherapy operating at 50 kV is increasing. For quality assurance it is important to identify dosimetry systems that can measure the absorbed doses in absolute terms which is difficult in this energy region. In this work a comparison is made between two dosimetry systems, EPR lithium formate dosimeters and radiochromic EBT2 film. Both types of dosimeters were irradiated simultaneously in a PMMA phantom using the Axxent EBS. Absorbed dose to water was determined at distances of 10 mm, 30 mm and 50 mm from the EBS. Results were traceable to different primary standards as regards to absorbed dose to water (EPR) and air kerma (EBT2). Monte Carlo simulations were used in absolute terms as a third estimate of absorbed dose to water. Agreement within the estimated expanded (k = 2) uncertainties (5% (EPR), 7% (EBT2)) was found between the results at 30 mm and 50 mm from the x-ray source. The same result was obtained in 4 repetitions of irradiation, indicating high precision in the measurements with both systems. At all distances, agreement between EPR and Monte Carlo simulations was shown as was also the case for the film measurements at 30mm and 50mm. At 10mm the geometry for the film measurements caused too large uncertainty in measured values depending on the exact position (within sub-mm distances) of the EBS and the 10 mm film results were exculded from comparison. This work has demonstrated good performance of the lithium formate EPR dosimetry system in accordance with earlier experiments at higher photon energies ((192)Ir HDR brachytherapy). It was also highlighted that there might be issues regarding the energy dependence and intrinsic efficiency of the EBT2 film that need to be considered for measurements using low energy sources.

摘要

对工作在50千伏的高剂量率(HDR)电子近距离放射治疗的兴趣正在增加。对于质量保证而言,识别能够绝对测量吸收剂量的剂量测定系统非常重要,而在这个能量区域这很困难。在这项工作中,对两种剂量测定系统——电子顺磁共振(EPR)甲酸锂剂量计和放射变色EBT2薄膜进行了比较。两种剂量计在聚甲基丙烯酸甲酯(PMMA)模体中使用Axxent EBS同时进行辐照。在距EBS 10毫米、30毫米和50毫米的距离处测定水的吸收剂量。就水的吸收剂量(EPR)和空气比释动能(EBT2)而言,结果可追溯到不同的初级标准。蒙特卡罗模拟被用作水吸收剂量的第三种绝对估计。在距X射线源30毫米和50毫米处的结果之间,在估计的扩展(k = 2)不确定度(5%(EPR),7%(EBT2))范围内发现了一致性。在4次重复辐照中获得了相同的结果,表明两种系统的测量具有高精度。在所有距离处,EPR与蒙特卡罗模拟之间都显示出一致性,30毫米和50毫米处的薄膜测量也是如此。在10毫米处,薄膜测量的几何形状根据EBS的确切位置(在亚毫米距离内)在测量值中造成了太大的不确定度,因此10毫米薄膜的结果被排除在比较之外。这项工作表明,甲酸锂EPR剂量测定系统具有良好的性能,这与早期在较高光子能量((192)铱HDR近距离放射治疗)下的实验一致。还强调了在使用低能量源进行测量时,EBT2薄膜的能量依赖性和固有效率可能存在需要考虑的问题。

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