Ward M J, Buss D C, Ellershaw J, Nash A, Routledge P A
Department of Clinical Pharmacology, University of Wales College of Medicine, Liandough Hospital, South Glamorgan.
Br J Clin Pharmacol. 1989 Nov;28(5):616-8. doi: 10.1111/j.1365-2125.1989.tb03552.x.
After intranasal administration of metoclopramide, (5 mg in 0.5 ml sterile water) the maximum plasma concentration of 13.5 +/- 7.3 (mean +/- s.d.) ng ml-1 was achieved. Absolute bioavailability was 50.5 +/- 29.5%, 110 +/- 41 min later. We conclude that the intranasal route does not allow rapid absorption of the drug and is not associated with greater bioavailability than the oral route.
经鼻内给予胃复安（5毫克溶于0.5毫升无菌水中）后，血浆最大浓度达到13.5±7.3（平均值±标准差）纳克/毫升，110±41分钟后，绝对生物利用度为50.5±29.5%。我们得出结论，鼻内给药途径不能使药物快速吸收，且与口服途径相比，生物利用度并未更高。
