Nikkhah Somayeh, Dolatian Mahrokh, Naghii Mohammad Reza, Zaeri Farid, Taheri Seyed Mojtaba
Department of Midwifery, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Midwifery, Faculty of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Complement Ther Clin Pract. 2015 May;21(2):79-83. doi: 10.1016/j.ctcp.2015.03.005. Epub 2015 Apr 4.
Primary dysmenorrhea refers to painful menstrual cramps without pelvic pathology. The condition is highly prevalent among women and exerts negative effects on their quality of life. Considering the evidence for anti-inflammatory properties of Boron, the present study aimed to determine the effects of Boron supplementation on the severity and duration of menstrual pain in female university students.
This triple-blind randomized clinical trial study recruited 113 university students. The participants were matched for the severity and duration of dysmenorrhea and randomly allocated into the case and control groups (n = 58 and 55, respectively). The case group consumed 10 mg/day Boron from two days before the menstrual flow until its third day. The control group received placebo capsules (similar to those distributed among the cases). All subjects were asked to take the capsules for two consecutive menstrual cycles. Pain severity (measured on a visual analog scale) and duration (in hours) were measured at baseline and during the two cycles.
The two groups had no significant differences in the severity and duration of pain at baseline. After the intervention, however, the severity and duration of pain were significantly lower in the case group than in the control group (P < 0.05).
Based on our findings, Boron supplementation can reduce the severity and duration of menstrual pain through exerting anti-inflammatory effects. In order to clarify the effects of Boron on dysmenorrhea, future studies are required to measure the levels of hormones and inflammatory biomarkers.
原发性痛经是指无盆腔病变的痛经。这种情况在女性中非常普遍，会对她们的生活质量产生负面影响。鉴于硼具有抗炎特性的证据，本研究旨在确定补充硼对女大学生痛经严重程度和持续时间的影响。
这项三盲随机临床试验研究招募了113名大学生。根据痛经的严重程度和持续时间对参与者进行匹配，然后随机分为病例组和对照组（分别为n = 58和55）。病例组从月经来潮前两天到第三天每天服用硼10毫克。对照组服用安慰剂胶囊（与发给病例组的胶囊相似）。所有受试者被要求连续两个月经周期服用胶囊。在基线和两个周期内测量疼痛严重程度（用视觉模拟量表测量）和持续时间（以小时为单位）。
两组在基线时疼痛的严重程度和持续时间没有显著差异。然而，干预后，病例组的疼痛严重程度和持续时间明显低于对照组（P < 0.05）。
根据我们的研究结果，补充硼可以通过发挥抗炎作用来减轻痛经的严重程度和持续时间。为了阐明硼对痛经的影响，未来的研究需要测量激素水平和炎症生物标志物。
