Niwa Tetsu, Aida Noriko, Fujii Yuta, Nozawa Kumiko, Imai Yutaka
Department of Radiology, Tokai University School of Medicine, Isehara, Japan; Department of Radiology, Kanagawa Children's Medical Center, Yokohama, Japan.
Department of Radiology, Kanagawa Children's Medical Center, Yokohama, Japan.
Brain Dev. 2015 Nov;37(10):967-73. doi: 10.1016/j.braindev.2015.04.003. Epub 2015 Apr 20.
To assess age-related changes in susceptibility-weighted imaging (SWI) and phase images of subependymal nodules (SENs) in neonates and children with tuberous sclerosis complex (TSC).
Images of 17 children (age range, 0-14years; mean, 5.5years) with TSC were retrospectively assessed. Changes in signals of SENs on SWI and filtered phase images were scored by two experienced radiologists using a three-point scale. The relation was assessed between patients' age and the average scores of SENs. The phase shift of SENs on the filtered phase image was also measured, and the correlation between age and phase shift was evaluated. Calcification in SENs on CT was compared to the finding on SWI and filtered phase image in four children.
No change in signal was found in neonates in SENs on both SWI and filtered phase image. There was a positive correlation between the average scores of SENs and patients' age on both SWI and filtered phase image (Spearman ρ=0.64, P=0.006; ρ=0.71, P=0.001, respectively). There was a negative correlation between the patients' age and mean phase shift (Spearman ρ=-0.86, P<0.001). Comparable or slight lower detectability of susceptibility changes was revealed in SENs on SWI and filtered phase image, compared to calcification on CT.
There are age-related changes in susceptibility and phase in SENs, which may reflect the appearance of calcification in children with TSC. No magnetically susceptible changes were detected in neonates, suggesting a lack of calcification.
评估结节性硬化症（TSC）新生儿和儿童的脑室内结节（SENs）在磁敏感加权成像（SWI）和相位图像中的年龄相关变化。
回顾性评估17例TSC患儿（年龄范围0 - 14岁；平均5.5岁）的图像。两名经验丰富的放射科医生使用三点量表对SENs在SWI和滤波相位图像上的信号变化进行评分。评估患者年龄与SENs平均评分之间的关系。还测量了滤波相位图像上SENs的相位偏移，并评估年龄与相位偏移之间的相关性。对4名儿童的SENs在CT上的钙化情况与SWI和滤波相位图像上的表现进行比较。
在SWI和滤波相位图像上，新生儿的SENs均未发现信号变化。在SWI和滤波相位图像上，SENs的平均评分与患者年龄均呈正相关（Spearman ρ分别为0.64，P = 0.006；ρ为0.71，P = 0.001）。患者年龄与平均相位偏移呈负相关（Spearman ρ = - 0.86，P < 0.001）。与CT上的钙化相比，SWI和滤波相位图像上SENs的磁敏感变化的可检测性相当或略低。
SENs的磁敏感性和相位存在年龄相关变化，这可能反映了TSC患儿钙化的出现。在新生儿中未检测到磁敏感变化，提示缺乏钙化。
