通过给受体复合物实现直接的芳环 C-H 三氟甲基化。
Direct Aromatic C-H Trifluoromethylation via an Electron-Donor-Acceptor Complex.
机构信息
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (P. R. China).
Institute of Theoretical and Computational Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (P. R. China).
出版信息
Chemistry. 2015 Jun 1;21(23):8355-9. doi: 10.1002/chem.201500896. Epub 2015 Apr 23.
A novel electron-donor-acceptor (EDA) complex-mediated direct C-H trifluoromethylation of arenes with Umemoto's reagent has been developed. This transformation has been enabled by an unprecedented EDA complex formed by Umemoto's reagent and an amine, which was supported by experiments and theoretical calculations. The radical-based methodology presented here allows to access highly-functionalized trifluoromethyl arenes in up to 81 % chemical yield.
一种新型的电子给体-受体（EDA）复合物介导的芳基与 Umemoto 试剂的直接 C-H 三氟甲基化反应已经被开发出来。这种转化是通过 Umemoto 试剂和胺形成的前所未有的 EDA 复合物来实现的，这一事实得到了实验和理论计算的支持。本文提出的基于自由基的方法可以高达 81%的化学收率得到高度官能化的三氟甲基芳基化合物。
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