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一种用于研究可生物降解聚合物支架自由膨胀行为的有限元策略。

A finite element strategy to investigate the free expansion behaviour of a biodegradable polymeric stent.

作者信息

Debusschere Nic, Segers Patrick, Dubruel Peter, Verhegghe Benedict, De Beule Matthieu

机构信息

IBiTech - bioMMeda - iMinds - Ghent University, De Pintelaan, 185 Ghent, Belgium.

IBiTech - bioMMeda - iMinds - Ghent University, De Pintelaan, 185 Ghent, Belgium.

出版信息

J Biomech. 2015 Jul 16;48(10):2012-8. doi: 10.1016/j.jbiomech.2015.03.024. Epub 2015 Apr 2.

Abstract

Bioresorbable stents represent a promising technological development within the field of cardiovascular angioplasty because of their ability to avoid long-term side effects of conventional stents such as in-stent restenosis, late stent thrombosis and fatigue induced strut fracture. Finite element simulations have proven to present a useful research tool for the design and mechanical analysis of stents. However, biodegradable stents pose new challenges because of their transitional mechanical behaviour. For polymeric biodegradable stents, viscoplastic effects have to be accounted for. This paper presents a method to analyse the mechanical behaviour of polymeric bioresorbable stents using an implicit finite-element solver. As an example, we investigate the mechanical behaviour of a commercially available bioresorbable stent. We examine how, due to the visco-elastic properties of the stent material, the balloon deployment rate influences the mechanical integrity of the stent.

摘要

生物可吸收支架因其能够避免传统支架的长期副作用,如支架内再狭窄、晚期支架血栓形成和疲劳诱导的支架断裂,而成为心血管血管成形术领域一项有前景的技术发展。有限元模拟已被证明是一种用于支架设计和力学分析的有用研究工具。然而,可生物降解支架因其过渡性力学行为带来了新的挑战。对于聚合物可生物降解支架,必须考虑粘塑性效应。本文提出了一种使用隐式有限元求解器分析聚合物生物可吸收支架力学行为的方法。作为一个例子,我们研究了一种市售生物可吸收支架的力学行为。我们研究了由于支架材料的粘弹性特性,球囊展开速率如何影响支架的机械完整性。

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