Wang Jing, Li Ruiqi, Ouyang Nengyong, Zheng Lingyan, Ou Songbang, Wang Wenjun
Center for Reproductive Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.
Center for Reproductive Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China. Email:
Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Feb;36(2):176-80.
To understand the clinical outcomes of frozen embryo transfer and fresh embryo transfer.
A retrospective analysis was conducted on the clinical data of 870 cases receiving embryo transfer at the Reproductive Medical Center of Sun Yat-Sen Memorial Hospital from January 2013 to March 2014, including 577 cases of in vitro fertilization and fresh embryo transfer, 118 cases of intracytoplasmic sperm injection and fresh embryo transfer and 175 cases of frozen thawed embryo transfer, to compare the clinical characteristics and outcomes between fresh embryo transfer group and frozen embryo transfer group (the patients who had received unsuccessful fresh embryo transfer). The frozen embryo transfer group was divided into pregnant subgroup and non pregnant subgroup to further comparison. Binary logistic regression analyses was performed to identify the influencing factors of pregnancy.
The implantation rate and clinical pregnancy rate were significantly lower in frozen embryo transfer group than in fresh embryo transfer group (26.27% vs. 31.98%, P = 0.01 and 47.43% vs. 65.18%, P < 0.001). The differences in abortion rate, biochemical pregnancy rate and fetal birth weight had no statistical significance between the two groups (P = 0.63, P = 0.17 and P = 0.33). The difference in age between pregnant subgroup and non pregnant subgroup was statistical significant (30.69 ± 3.37 years vs. 32.00 ± 5.09 years, P = 0.03), but no significant differences were found in BMI, duration of infertility and basic endocrine between the two subgroups. Binary logistic regression analysis showed that receiving frozen embryo transfer or not (P < 0.001), wife's age (P < 0.001), BMI (P = 0.011) and number of top quality embryos (P < 0.001) were influencing factors of pregnancy.
Lower implantation rate and clinical pregnancy rate was observed in the patients in frozen embryo transfer group, who had received unsuccessful fresh embryo transfer, but no increase of abortion rate, influence on fetal birth weight and adverse pregnancy outcome were observed.
了解冻融胚胎移植与新鲜胚胎移植的临床结局。
回顾性分析2013年1月至2014年3月在中山大学孙逸仙纪念医院生殖医学中心接受胚胎移植的870例患者的临床资料，其中体外受精新鲜胚胎移植577例、卵胞浆内单精子注射新鲜胚胎移植118例、冻融胚胎移植175例，比较新鲜胚胎移植组与冻融胚胎移植组（新鲜胚胎移植未成功患者）的临床特征及结局。将冻融胚胎移植组分为妊娠亚组和未妊娠亚组进一步比较。采用二元logistic回归分析确定妊娠的影响因素。
冻融胚胎移植组的种植率和临床妊娠率显著低于新鲜胚胎移植组（26.27%对31.98%，P = 0.01；47.43%对65.18%，P < 0.001）。两组间流产率、生化妊娠率和胎儿出生体重差异无统计学意义（P = 0.63、P = 0.17和P = 0.33）。妊娠亚组与未妊娠亚组年龄差异有统计学意义（30.69±3.37岁对32.00±5.09岁，P = 0.03），但两组亚组间BMI、不孕年限和基础内分泌指标差异无统计学意义。二元logistic回归分析显示，是否接受冻融胚胎移植（P < 0.001）、妻子年龄（P < 0.001）、BMI（P = 0.011）和优质胚胎数（P < 0.001）是妊娠的影响因素。
冻融胚胎移植组新鲜胚胎移植未成功患者的种植率和临床妊娠率较低，但未观察到流产率增加、对胎儿出生体重的影响及不良妊娠结局。
