Silva Ruwan A, Dubovy Sander R, Hess Ditte, Stratton Rick, Murray Timothy G
Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida.
Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida.
J AAPOS. 2015 Jun;19(3):268-70. doi: 10.1016/j.jaapos.2015.01.015. Epub 2015 Apr 21.
Intra-arterial melphalan chemotherapy (IAC) continues to demonstrate excellent utility in the treatment of retinoblastoma. We present the case of a 3-month-old boy diagnosed with with unilateral, advanced stage 5B retinoblastoma and a Coats' response in the right eye. After laser therapy he received 3 doses of IAC. Intraretinal hemorrhaging, first noted after the second dose and worsening after the third, preceded complex exudative retinal detachment. With little visual potential and evidence of atropy, the eye was enucleated. This case illustrates that intraretinal hemorrhage may serve as an early predictor of treatment failure.
动脉内美法仑化疗（IAC）在视网膜母细胞瘤的治疗中持续展现出卓越的效用。我们报告一例3个月大男孩的病例，其被诊断为单侧5B期晚期视网膜母细胞瘤，右眼有科茨氏反应。激光治疗后，他接受了3剂IAC。视网膜内出血在第二剂后首次出现，并在第三剂后加重，随后发生了复杂的渗出性视网膜脱离。由于视力潜力极小且有萎缩迹象，该眼被摘除。此病例表明视网膜内出血可能是治疗失败的早期预测指标。
